Results 41 to 50 of about 113,305 (267)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Neuropatia silenciosa em portadores de hanseníase na cidade de Fortaleza, Ceará, Brasil Silent neuropathy in patients with leprosy in the city of Fortaleza, Ceará State, Brazil

Cadernos de Saúde Pública, 2011
Uma das formas da hanseníase é a neuropatia silenciosa que consiste em perda progressiva da função motora ou sensorial na ausência de dor e hipersensibilidade dos nervos.
Vyna Maria Cruz Leite, José Wellington de Oliveira Lima, Heitor de Sá Gonçalves   +2 more
doaj   +1 more source

Pathophysiology of the underactive bladder [PDF]

Investigative and Clinical Urology, 2017
Underactive bladder (UAB), which has been described as a symptom complex suggestive of detrusor underactivity, is usually characterized by prolonged urination time with or without a sensation of incomplete bladder emptying, usually with hesitancy ...
Naoki Aizawa , Yasuhiko Igawa
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Examining the relation of personality factors to substance use disorder by explanatory item response modeling of DSM-5 symptoms.

PLoS ONE, 2019
This paper explores how personality factors affect substance use disorders (SUDs) using explanatory item response modeling (EIRM). A total of 606 Chinese illicit drug users participated in our study.
Fu Chen, Hongmei Yang, Okan Bulut, Ying Cui, Tao Xin   +4 more
doaj   +1 more source

Clinical Features of Idiopathic Paroxysmal Kinesigenic Dyskinesia

Pediatric Neurology Briefs, 2004
The clinical features of 121 patients, referred for genetic study, with a presumptive diagnosis of idiopathic paroxysmal kinesigenic dyskinesia (PKD), were reviewed by a multicenter panel and reported from the University of Calfornia, San Francisco.
J Gordon Millichap
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

An Exploration of Unani Concept of Pain with Conventional Medicine [PDF]

Journal of Research on History of Medicine, 2023
The intention of medicine is to retain and restore health and relieve suffering. Understanding pain is essential to achieving any one of these goals.
Sana Kauser Ahmed, Sanila Zafar, Tasfiya Ansari   +2 more
doaj  

Sensation‐to‐cognition cortical streams in attention‐deficit/hyperactivity disorder

Human Brain Mapping, 2015
AbstractWe sought to determine whether functional connectivity streams that link sensory, attentional, and higher‐order cognitive circuits are atypical in attention‐deficit/hyperactivity disorder (ADHD). We applied a graph‐theory method to the resting‐state functional magnetic resonance imaging data of 120 children with ADHD and 120 age‐matched ...
Carmona, Susana, Hoekzema, E, Castellanos, Francisco X, García-García, David, Lage-Castellanos, Agustín, Van Dijk, Koene R A, Navas-Sánchez, Francisco J, Martínez, Kenia, Desco, Manuel, Sepulcre, Jorge   +9 more
openaire   +5 more sources