Results 51 to 60 of about 207,441 (327)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Sensation seeking and impulsivity as predictors of aggression in adolescents [PDF]
Psychology, Society & Education, 2016 Adolescence is a stage in which impulsivity and sensation seeking are presented as two factors that come together with a wide range of changes inherent to adolescent development.
José J. GÁZQUEZ +3 more
doaj
Online and live regular poker players: Do they differ in impulsive sensation seeking and gambling practice? [PDF]
, 2016 Background and aims Online gambling appears to have special features, such as anonymity, speed of play and permanent availability, which may contribute to the facilitation and increase in gambling practice, potentially leading to problem gambling.
Barrault, Servane, Varescon, Isabelle
core +5 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Role of Sensation Seeking in Sensitivity to d-amphetamine Reinforcement [PDF]
, 2014 Psychomotor stimulant abuse is a significant public health problem. While many individuals experiment with stimulants, there is marked variability in individuals\u27 behavioral and subjective response to these drugs and these differences may be ...
Patrick, Mollie E.
core +1 more source
Potential benefits of an adaptive forward collision warning system [PDF]
, 2008 Forward collision warning (FCW) systems can reduce rear-end vehicle collisions. However, if the presentation of warnings is perceived as mistimed, trust in the system is diminished and drivers become less likely to respond appropriately.
A. Hamish Jamson +17 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
A Study of the Relationship between Sensation Seeking and Marital Satisfaction
روانشناسی بالینی و شخصیت, 2005 The purpose of the present study was to investigate the relationship between sensation seeking and: marital satisfaction, gender, education, marital duration and age differences of the couples.
M.B. Kajbaf, H. Neshatdust, Gh. Khaloei
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Sensation Seeking and Adaptation in Parabonauts
Frontiers in Psychology, 2018 Evidence from extreme environments suggests that there are relationships between difficulties of adaptation and psychological factors such as personality.
Aurélie Collado +4 more
doaj +1 more source