Results 101 to 110 of about 6,140,004 (297)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2015 Making Sense of Crime brings together experts in the causes of crime and measures to reduce it, who share insights from reliable research evidence. This evidence reveals how misleading the political debate on crime is.
Jonathan Shepherd +9 more
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International Journal of Integrated Care, 2015 Clair Agnes Henderson, Eddie Fraser
doaj +3 more sources
Forum: Qualitative Social ResearchThe use of DERVIN's sense-making methodology in a study of non-Māori librarians learning about and engaging with mātauranga Māori [Māori knowledge] led to a number of useful findings, but also revealed a raft of methodological challenges.
Kathryn Oxborrow Vambe
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2001 This book provides a compelling analysis of the conditions in which women are sustained within prostitution in Britain at the end of the millennium. Based on a major empirical study, it is a unique glimpse into how some women, who live lives completely ...
Phoenix, J, Phoenix, J.
core
Interprofessional sense-making in the emergency department: A SenseMaker study. [PDF]
PLoS One, 2023 Cunningham C, Vosloo M, Wallis LA.
europepmc +1 more source