Results 101 to 110 of about 6,899,097 (297)

Making Sense Beauty, Creativity, and Healing

open access: yes, 2014
Regardless of field, from the art world to healthcare delivery, there is a growing need for practically useful theory and theoretically informed practice.
Lee, Bandy   +2 more
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Making Sense of it All : Conducting KSTE with Canadian Public Health [PDF]

open access: yes, 2007
National Collaborating Centre for Determinants of Health. (2007). A report on the NCC’s 2nd annual summer institute: Making sense of it all: Conducting KSTE with Canadian public health. Antigonish, NS: Author. ISBN 978-1-926823-04-

core  

On Making Sense of Recipes

open access: yesHumana.Mente: Journal of Philosophical Studies, 2020
In this paper I address some ways of making sense of, and so of understanding, recipes. I first make clear the plausibility of a recipe having aesthetic significance, thus situating recipes as continuous with other aspects of our lives and experiences ...
Craig Fox
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Making sense of subjective experience

open access: yes, 2010
This chapter explains how subjective experience needs to be considered alongside objective and rational forms of evidence. It will help you to start to make sense of your subjective experience and identify how this fits with other forms of evidence.
Howatson-Jones, L.
core  

Making Sense of Denial in Sexual Offenders

open access: yes, 2014
Denial in sexual offenders represents the first barrier to successful treatment a clinician is likely to face. Most sex offender treatment programs devote significant time to overcoming denial, with most programs having a focus on disclosure and ...
Thorne, K.   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Making Sense in Ayrshire

open access: yesInternational Journal of Integrated Care, 2015
Clair Agnes Henderson, Eddie Fraser
doaj   +3 more sources

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