Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Development of the COMPASS model of endometriosis: A COmprehensive model of pain encompassing agency, systemic factors and sense making. [PDF]
Br J Health PsycholPickup B, Sharpe L, Todd J.
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Family Sense-Making After a Down Syndrome Diagnosis. [PDF]
Qual Health Res, 2020 Clark L +5 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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The Scottish Simulation 'KSDP' Design Framework: a sense-making and ordered approach for building aligned simulation programmes. [PDF]
Adv Simul (Lond)Oliver N, Edgar S, Mellanby E, May A.
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Sense-Making, Mutual Learning and Cognitive Shifts When Applying Systems Thinking in Public Health - Examples From Sweden Comment on "What Can Policy-Makers Get Out of Systems Thinking? Policy Partners' Experiences of a Systems-Focused Research Collaboration in Preventive Health". [PDF]
Int J Health Policy Manag, 2021 Nyström ME, Tolf S, Strehlenert H.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Bridging Employees' Perceptions of Corporate Social Responsibility, Sense-Making for Meaningfulness, and Work Engagement for Successful Self-Regulation. [PDF]
Behav Sci (Basel)Wang Z, Carroll S, Wang EH.
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Diaries as technologies for sense-making and self-transformation in times of vulnerability.
, 2023 Marcos MJB, Zittoun T, Gillespie A.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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