Results 171 to 180 of about 6,140,004 (297)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Making sense of the future [PDF]

Journal of Tourism Futures, 2019
Ian Seymour Yeoman
doaj   +1 more source

"Coming Home Is the Hardest Part": An Interpretative Phenomenological Analysis of Sense Making in Military Postdeployment Reintegration. [PDF]

J Community Psychol
Luethke TN, Thompson HL, Folk G.
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Development of the COMPASS model of endometriosis: A COmprehensive model of pain encompassing agency, systemic factors and sense making. [PDF]

Br J Health Psychol
Pickup B, Sharpe L, Todd J.
europepmc   +1 more source

Family Sense-Making After a Down Syndrome Diagnosis. [PDF]

Qual Health Res, 2020
Clark L, Canary HE, McDougle K, Perkins R, Tadesse R, Holton AE.   +5 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The Scottish Simulation 'KSDP' Design Framework: a sense-making and ordered approach for building aligned simulation programmes. [PDF]

Adv Simul (Lond)
Oliver N, Edgar S, Mellanby E, May A.
europepmc   +1 more source

Sense-Making, Mutual Learning and Cognitive Shifts When Applying Systems Thinking in Public Health - Examples From Sweden Comment on "What Can Policy-Makers Get Out of Systems Thinking? Policy Partners' Experiences of a Systems-Focused Research Collaboration in Preventive Health". [PDF]

Int J Health Policy Manag, 2021
Nyström ME, Tolf S, Strehlenert H.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source