Results 151 to 160 of about 6,140,004 (297)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Sense-Making and Gratitude in the Aftermath of Hurricane Helene. [PDF]

J Clin Psychol
Britt NF, Kowalski RM, Dodson C.
europepmc   +1 more source

Optimal Sense-Making and Resilience in Times of Pandemic: Integrating Rationality and Meaning in Psychotherapy. [PDF]

Front Psychol, 2021
Russo-Netzer P, Ameli M.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Enhancing person-centered obstetric care: A qualitative grounded theory study on perception formation and sense-making during childbirth. [PDF]

Eur J Midwifery
Okumu MR, Bach L, Haid-Schmallenberg L, Karbach U, McKee L, Stevens NR, Volkert A, Scholten N.   +7 more
europepmc   +1 more source

Virtual Teaming: Leveraging Team Science Sense-Making During COVID-19. [PDF]

J Patient Exp, 2021
Portman DG, Thirlwell S, Donovan KA, Ellington L.   +3 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Sense-making as digitalization. Measuring, counting, and calculating as fundamental processes of digital 'Bildung'. [PDF]

Front Sociol
Manhart S.
europepmc   +1 more source

Where horizontal and vertical surveillances meet: Sense-making of US COVID-19 contact-tracing apps during a health crisis. [PDF]

Mob Media Commun, 2022
Baik JS, Jang E.
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source