Results 241 to 250 of about 8,535,407 (297)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Relating physical exercise to "lying flat" among Chinese college students: the chain mediation of temporal focus and the sense of meaning in life. [PDF]

Front Psychol
Cao X, Han Y.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Exploring the role of admiration in mitigating athlete burnout: an emotional perspective. [PDF]

Front Psychol
Xu W, Tian S, Song T, Chen S, Pan Y.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

From the body to the mind: interoception and sense of agency as mechanisms of depression reduction in the Body-Mind Axial Awareness (BMAA). [PDF]

Front Psychol
Lien YW, Teng SC, Wei LY.
europepmc   +1 more source

Autonomous enhancement or emotional depletion? The dual-path mechanism of AI usage on employees' work behavior. [PDF]

Front Public Health
Jiang D, Liu Y, Gu X.
europepmc   +1 more source

The Healing Hermeneutics of Carnal Caring in Neonatal Intensive Care Units. [PDF]

Nurs Philos
Wepener C, Wepener C, Gerber B.
europepmc   +1 more source

Making sense of activity-based workplaces: perspectives from staff in a municipal setting. [PDF]

Int J Qual Stud Health Well-being
Wall E, Löfstrand P, Vinberg S, Selander J.   +3 more
europepmc   +1 more source

Understanding the Psychological Impacts of Shielding From COVID-19 for Immunocompromised Individuals. [PDF]

Health Expect
Gray A, Barnett J, Bernardi L, Daniels J.   +3 more
europepmc   +1 more source