Results 51 to 60 of about 4,662 (216)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Simulation of the Impacts of Urbanization on Winter Meteorological Fields over the Pearl River Delta Region

Advances in Meteorology, 2017
The influences of urbanization on weather in Guangdong Province, China, were studied using the Weather Research and Forecasting model from 31 December 2009 through 3 January 2010.
Naixing Luo, Liping Zeng, Wenshi Lin, Fangzhou Li, Baolin Jiang, Jiangnan Li   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Re-estimation of the vertical sensible heat flux by determining the environmental temperature on a single-point tower measurement

Frontiers in Earth Science
Surface energy balance has always been a goal of those studying the Earth’s climate system. However, many studies have demonstrated that turbulent heat fluxes are usually underestimated by eddy covariance (EC) measurements, such that the energy balance ...
Yongfeng Qi, Yongfeng Qi, Xiaodong Shang, Xiaodong Shang, Guiying Chen, Guiying Chen, Zhiqiu Gao, Xueyan Bi, Linghui Yu, Linghui Yu, Huabin Mao, Huabin Mao   +11 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

DINÂMICA DO BALANÇO DE ENERGIA SOBRE O AÇUDE ORÓS E SUAS ADJACÊNCIAS

Revista Caatinga, 2012
This paper aimed to investigate the dynamic of energy balance components over Orós reservoir and neighboring areas using Surface Energy Balance Algorithm for Land (SEBAL) and TM-Landsat 5 images.
FRANCISCO DIRCEU DUARTE ARRAES, EUNICE MAIA DE ANDRADE, BERNARDO BARBOSA DA SILVA   +2 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Summer soil moisture-convective precipitation coupling in Northern China at different timescales

Journal of Hydrology: Regional Studies
Land-atmosphere coupling plays an important role in regional precipitation and climate change, but the coupling characteristics at different time scales remain controversial.
Hongwei Yang, Zesu Yang, Hang He
doaj   +1 more source

Downwelling longwave radiation and sensible heat flux observations are critical for surface temperature and emissivity estimation from flux tower data. [PDF]

Sci Rep, 2022
Thakur G, Schymanski SJ, Mallick K, Trebs I, Sulis M.   +4 more
europepmc   +1 more source