Results 191 to 200 of about 1,047,682 (240)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Sensing and sensing-of-sensing with drones

2021 International Conference on Electrical, Computer, Communications and Mechatronics Engineering (ICECCME), 2021
Vehicles such as cars, mobility scooters, wheelchairs, and the like are becoming partially or fully automated (i.e. equipped with driver-assist technologies or completely self-driving technologies). These technologies rely heavily on sensors such as vision (cameras), radar, sonar, etc..
Steve Mann, Samir Khaki, Jaden Bhimani, Gael Verges, Faraz Sadrzadeh-Afsharazar   +4 more
openaire   +1 more source

Senses of 'Perceive' Or Senses of 'Senses of "Perceive"'?

Analysis, 1963
IS there a sense of 'perceive' in which what is perceived need not really exist? In The Foundations of Empirical Knowledge (Ch. I) Ayer tries to show that there is; in Sense and Sensibilia (Ch. IX) Austin tries to show that there is not; and in "Senses and Sensibilia" (ANALYSIS 23.2, Dec. 1962) King-Farlow tries to show that there is a sense of 'sense'
openaire   +1 more source

Clinical Sense, Social Sense, Common Sense

JAMA: The Journal of the American Medical Association, 1969
As I address this House of Delegates for the last time as President of the Association, let me express my great pride in the medical profession and the American Medical Association. I am grateful to hundreds of members of the Association and to its staff who during the past year have so ably and effectively pushed toward its goals and have helped me so
openaire   +2 more sources

Senses for senses

Australasian Journal of Philosophy, 2009
If two subjects have phenomenally identical experiences, there is an important sense in which the way the world appears to them is precisely the same.
openaire   +1 more source