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Mechanisms of endothelial flow sensing

Nature Cardiovascular Research, 2023
Fluid shear stress plays a key role in sculpting blood vessels during development, in adult vascular homeostasis and in vascular pathologies. During evolution, endothelial cells evolved several mechanosensors that convert physical forces into biochemical signals, a process termed mechanotransduction.
Claire Aitken   +3 more
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Gut sensing mechanisms

Current Gastroenterology Reports, 2009
The mechanisms by which the gut senses and responds to nutrients involve the interplay of multiple complex pathways. In addition to regulating digestion and absorption, the pathways stimulated by molecules in the gut lumen mediate gastric motility, food intake, and satiety. Furthermore, protective mechanisms are activated as necessary to prevent injury,
Arushi, deFonseka, Jonathan, Kaunitz
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Bacterial sensing mechanism revealed

Science, 2017
Structural Biology Escherichia coli use a transmembrane sensor protein to sense nitrate in their external environment and initiate a biochemical response. Gushchin et al. compared crystal structures of portions of the NarQ receptor that included the transmembrane helices in ligand-bound or unbound states. The structures suggest a signaling mechanism by
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Statistical Mechanics of Compressed Sensing

Physical Review Letters, 2010
Compressed sensing (CS) is an important recent advance that shows how to reconstruct sparse high dimensional signals from surprisingly small numbers of random measurements. The nonlinear nature of the reconstruction process poses a challenge to understanding the performance of CS.
Surya, Ganguli, Haim, Sompolinsky
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Cellular Mechanism of Oxygen Sensing

Annual Review of Physiology, 2001
▪ Abstract  O2sensing is a fundamental biological process necessary for adaptation of living organisms to variable habitats and physiological situations. Cellular responses to hypoxia can be acute or chronic. Acute responses rely mainly on O2-regulated ion channels, which mediate adaptive changes in cell excitability, contractility, and secretory ...
J, Lopez-Barneo   +2 more
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Tactile Sensing Mechanisms

The International Journal of Robotics Research, 1990
This paper has three main themes: design of a cylindrical tactile sensor, mechanical analysis using planar linear elas ticity models, and signal analysis for determining basic infor mation about the applied contact. An analysis of appropriate sensor depth has been used to allow accurate localization of contacts and reduced spatial aliasing.
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Intracellular Mechanisms of Oxygen Sensing

Biochemistry (Moscow), 2020
The review describes molecular mechanisms for sensing oxygen levels in various compartments of animal cell. Several pathways for intracellular oxygen sensing are discussed together with details of functioning of the near-membrane and cytoplasmic pools of molecular components in hypoxic cells.
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Mechanisms of Membrane Curvature Sensing

Annual Review of Biochemistry, 2011
Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs or domains that recognize the curvature, concave or convex, deep or shallow, of lipid membranes. These sensors contrast with classical lipid-binding domains by their extended structure and, sometimes, counterintuitive chemistry.
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Sense Organ Mechanisms

1991
Sense organs, or sensory receptors, form the interface between the animal’s environment on the one hand and its nervous system on the other. This interface is with both the internal and external environments and it is the function of the sense organs to monitor these environments.
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Sense Organs: Mechanical and Chemical Senses

1972
THE SIMPLEST mechanical sense is that of touch. This may be subserved by (i) receptors of contact projecting from the surface of the body, (ii) sense organs stimulated by the strains set up in the cuticle by pressure, or (iii) organs sensitive to changes of tension within the body.
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