Results 81 to 90 of about 3,965,120 (318)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-Wavelength Excitable Multicolor Upconversion and Ratiometric Luminescence Thermometry of Yb³⁺/Er³⁺ Co-Doped NaYGeO₄ Microcrystals

Molecules
Excitation wavelength controllable lanthanide upconversion allows for real-time manipulation of luminescent color in a composition-fixed material, which has been proven to be conducive to a variety of applications, such as optical anti-counterfeiting and
Hui Zeng, Yangbo Wang, Xiaoyi Zhang, Xiangbing Bu, Zongyi Liu, Huaiyong Li   +5 more
doaj   +1 more source

Influence of plant density and biological products on the formation of seed yield of maize lines under irrigation conditions [PDF]

BIO Web of Conferences
Treatment with biological products resulted in an increase in the area of the assimilation apparatus by 1.7 to 2.4 thousand m²/ha.The application of Bio-gel led to an increase in leaf surface by 1.7 thousand m2/ha or 5.3%, and the treatment with Helafit ...
Marchenko Tetiana, Piliarska Olena, Kiyamova Dilfuza, Musaev Sharof   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Identification of Tamoxifen-Resistant Breast Cancer Cell Lines and Drug Response Signature

Frontiers in Molecular Biosciences, 2020
Breast cancer cell lines are frequently used to elucidate the molecular mechanisms of the disease. However, a large proportion of cell lines are affected by problems such as mislabeling and cross-contamination.
Qingzhou Guan, Xuekun Song, Zhenzhen Zhang, Yizhi Zhang, Yating Chen, Jing Li   +5 more
doaj   +1 more source

A moving-part-free protamine-sensitive polymeric membrane electrode for sensitive biomedical analyses [PDF]

, 2012
Traditional potentiometric polyion-sensitive electrodes can only work effectively in samples with vigorous convection fulfilled by magnetic stirrer, electrode rotator, or other moving components.
Wang, Qing, Wang, Xuewei, Qin, Wei
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Heterologous Expression and Enzymatic Properties of β-Glucuronidase from Clostridium perfringens and Its Application in Bilirubin Transformation

Microorganisms
β-glucuronidase is an important hydrolase, which plays an important role in drug metabolism, clinical diagnostics, and biotransformation. This study focuses on the heterologous expression, isolation, purification, and its enzymatic properties of β ...
Qianlin Wu, Qing Guo, Fo Yang, Mengru Li, Yumeng Zhu, Binpeng Xu, Lu Zhao, Shanshan Zhang, Youyu Xie, Feng Li, Xiaomin Wu, Dayong Xu   +11 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source