Results 101 to 110 of about 2,243,062 (248)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Improved sensitive graph based fair representation learning in knowledge-aware recommendation

四川大学学报. 自然科学版
Existing knowledge-aware recommendation systems， due to a lack of inherent fairness guarantees when integrating knowledge graphs， implicitly learn potential biases embedded in knowledge relations， which consequently leads to recommendation fairness ...
SUN Si-Yu, YANG Yue-Ting, SHI Wei, JU Sheng-Gen   +3 more
doaj  

Attribute-Driven Design (ADD), Version 2.0

, 2018
This report revises the Attribute-Driven Design (ADD) method that was developed by the Carnegie Mellon Software Engineering Institute. The motivation for revising ADD came from practitioners who use the method and want ADD to be easier to learn ...
Paulo F. Merson (5405426), Len Bass (5405420), Robert Wojcik (5406128), Paul C Clements (5405429), Felix Bachmann (5406131), Robert Nord (5405519), William Wood (5405513)   +6 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Voice Fence Wall: User-optional voice privacy transmission

Journal of Information and Intelligence
Sensors are widely applied in the collection of voice data. Since many attributes of voice data are sensitive such as user emotions, identity, raw voice collection may lead serious privacy threat.
Li Luo, Yining Liu
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Enhanced cloud storage access control scheme based on attribute

Tongxin xuebao, 2013
In order to ensure the security of data and privacy in cloud storage, an enhanced cloud storage access control solution based on attribute was proposed.
De-hua NIU, Jian-feng MA, Zhuo MA, Chen-nan LI, Lei WANG   +4 more
doaj   +2 more sources

MAP-GAN: multi-attribute facial privacy protection model without losing identification

Cybersecurity
In recent years, the proliferation of facial image collection systems coupled with significant advancements in machine learning-driven image analysis techniques has posed formidable challenges to protecting individuals’ privacy information, raising ...
Yue Wang, Meng Yue, Zhiqiang Yao, Zheyu Chen, Renyuan Hu, Biao Jin   +5 more
doaj   +1 more source