Results 241 to 250 of about 10,391,048 (325)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Beyond Chordoma: A Comprehensive Review of Sacral Lesions. [PDF]

Curr Oncol
Savarese LG, Papalexis N, Hernandes MA, Facchini G, Miceli M, Nogueira-Barbosa MH.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

High miR-202-5p Expression at Initial Diagnosis is Associated With Tyrosine Kinase Inhibitor Resistance In Chronic Myeloid Leukemia-A Result From a Nested Case-Control Study. [PDF]

EJHaem
Nie ZY, Wang J, Zhao ZY, Zuo YB, Li JA, Gong TJ.   +5 more
europepmc   +1 more source

Effects of Simulated Precipitation Treatment on Denitrifying Microbial Communities in the Wayan Mountains. [PDF]

Biology (Basel)
Zhou S, Chen K, Zhang N, Zhou Z, Wang S.
europepmc   +1 more source

Beyond the standard: Rethinking Likert scale use in measuring patient satisfaction at public health center in Indonesia. [PDF]

J Public Health Res
Astiena AK, Asdi Y, Hadiguna RA.
europepmc   +1 more source

Studying clonal heterogeneity of acute myeloid leukemia under nutrient and chemotherapy stress. [PDF]

Blood Adv
Mayerhofer C, Crompton E, Mayerhofer E, Kristiansen T, Fukushima T, Keyes S, Sharda A, Li D, Da Silva C, Shrestha D, Kiem A, Feuchtinger T, Scadden DT, Miller PG.   +13 more
europepmc   +1 more source

Modeling <i>APOE</i>, morbidity, and mortality: a reproducibility challenge for genetic epidemiology. [PDF]

Front Genet
Häggström Gunfridsson E.
europepmc   +1 more source

Fear of progression profiles in parents of children with cancer and their impact on psychological distress: The mediating role of sense of coherence. [PDF]

Asia Pac J Oncol Nurs
Ma G, Jiao P, Zeng X, Ding Q, Huang Z, Gu C, Xie J.   +6 more
europepmc   +1 more source