Results 101 to 110 of about 2,651,129 (312)
Global Sensitivity Analysis of Large Reaction Mechanisms Using Fourier Amplitude Sensitivity Test
Journal of Chemistry, 2018 Global sensitivity analysis (GSA) of large chemical reaction mechanisms remains a challenge since the model with uncertainties in the large number of input parameters provides large dimension of input parameter space and tends to be difficult to evaluate
Shengqiang Lin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Optimization of structures subjected to dynamic load: deterministic and probabilistic methods
REM: International Engineering JournalThis paper deals with the deterministic and probabilistic optimization of structures against bending when submitted to dynamic loads. The deterministic optimization problem considers the plate submitted to a time varying load while the probabilistic one ...
Élcio Cassimiro Alves
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Ethanol sensitivity of sporulation in Bacillus subtilis: a new tool for the analysis of the sporulation process [PDF]
, 1976 Jean‐Pierre Bohin +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Derivative-Variance Hybrid Global Sensitivity Measure with Optimal Sampling Method Selection
MathematicsThis paper proposes a derivative-variance hybrid global sensitivity measure with optimal sampling method selection. The proposed sensitivity measure is as computationally efficient as the derivative-based global sensitivity measure, which also serves as ...
Jiacheng Liu +5 more
doaj +1 more source
Genetic analysis of adenovirus type 2 III. Temperature sensitivity of processing viral proteins [PDF]
, 1976 Joseph Weber
openalex +1 more source