Results 101 to 110 of about 29,659,346 (383)
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source
Sensitivity and uncertainty analysis
, 2023 This NEXOGENESIS Deliverable describes the methodological approaches to be employed within the System Dynamics Models (SDMs) for each of the five Case Studiesregarding: scenario analysis; sensitivity analysis; what-if testing; and uncertainty analysis. It outlines why these methods are essential for improved policy-relevant information.
Janez Sušnik +5 more
openaire +2 more sources
FEBS Letters, EarlyView.Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley +1 more source
Stress Sensitivity Analysis of the Beam and Shell Finite Elements
Communications, 2009 The stress sensitivity analysis in conjunction with finite elements method represents an important tool for the influence analysis of the structural parameters.
Milan Saga, Milan Vasko
doaj +1 more source
Sensitivity analysis methods in the biomedical sciences. [PDF]
Mathematical Biosciences, 2020 George Qian, A. Mahdi
semanticscholar +1 more source
New Uses for Sensitivity Analysis: How Different Movement Tasks Effect Limb Model Parameter Sensitivity [PDF]
, 1984 Original results for a newly developed eight-order nonlinear limb antagonistic muscle model of elbow flexion and extension are presented. A wider variety of sensitivity analysis techniques are used and a systematic protocol is established that shows how ...
Stark, L., Winters, J. M.
core +1 more source
Sensitivity Analysis: An Operational Picture
Water Resources Research, 2023 AbstractModeling is crucial to understand the behavior of environmental systems. A deeper comprehension of a model can be aided by global sensitivity analysis (GSA). Variability ascribed to model variables could have a stochastic (i.e., lack of knowledge) or an operational (i.e., possible design values) origin.
openaire +3 more sources
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Methods for global sensitivity analysis in life cycle assessment
The International Journal of Life Cycle Assessment, 2017 PurposeInput parameters required to quantify environmental impact in life cycle assessment (LCA) can be uncertain due to e.g. temporal variability or unknowns about the true value of emission factors.
E. Groen +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source