Results 101 to 110 of about 3,327,512 (288)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development and Application of a Sensitivity and Uncertainty Analysis Framework for Safety Analysis of Molten Salt Reactors

Energies
To provide reliable safety margins in reactor design and safety analysis, the best estimate plus uncertainty (BEPU) analysis, which is recommended by the International Atomic Energy Agency (IAEA), has drawn increasing attention worldwide.
Haijun Liu, Rui Li, Xiandi Zuo, Maosong Cheng, Shichao Chen, Zhimin Dai   +5 more
doaj   +1 more source

Sensitivity Analysis of BLISK Airfoil Wear †

International Journal of Turbomachinery, Propulsion and Power, 2018
The decreasing performance of jet engines during operation is a major concern for airlines and maintenance companies. Among other effects, the erosion of high-pressure compressor (HPC) blades is a critical one and leads to a changed aerodynamic behavior,
Andreas Kellersmann, Gerald Reitz, Jens Friedrichs   +2 more
doaj   +1 more source

Sensitivity-Analysis in biomechanical modelling and its relevance for total hip arthroplasty – An application oriented analysis

, 2019
original Study: Sensitivity analysis, Pauwel model, total hip ...
Ebeling (6441485)
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Sensitivity analysis and uncertainty quantification of stiffness modulus using indirect tensile test

International Journal of Applied Mechanics and Engineering
The stiffness modulus is a critical element in pavement engineering, as its accurate measurement directly reflects the load-bearing capacity of the pavement section.
Hicham Mezouara, Houcine Zniker, Ikram Feddal, Mohammed Khalil El Kouifat, Mohamed El Hasnaoui   +4 more
doaj   +1 more source

Global sensitivity analysis of computer models with functional inputs

, 2007
International audienceGlobal sensitivity analysis is used to quantify the influence of uncertain input parameters on the response variability of a numerical model.
Iooss, Bertrand, B. Iooss, Ribatet, Mathieu, M. Ribatet   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Cluster sample inference using sensitivity analysis: the case with few groups [PDF]

This paper re-examines inference for cluster samples. Sensitivity analysis is proposed as a new method to perform inference when the number of groups is small.
Vikström, Johan
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source