Results 151 to 160 of about 29,659,346 (383)
Derivative-Variance Hybrid Global Sensitivity Measure with Optimal Sampling Method Selection
MathematicsThis paper proposes a derivative-variance hybrid global sensitivity measure with optimal sampling method selection. The proposed sensitivity measure is as computationally efficient as the derivative-based global sensitivity measure, which also serves as ...
Jiacheng Liu +5 more
doaj +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Genetic analysis of adenovirus type 2 III. Temperature sensitivity of processing viral proteins [PDF]
, 1976 Joseph Weber
openalex +1 more source
The uniform general signed rank test and its design sensitivity
, 2019 A sensitivity analysis in an observational study tests whether the qualitative conclusions of an analysis would change if we were to allow for the possibility of limited bias due to confounding.
Howard, Steven R., Pimentel, Samuel D.
core
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Ethanol sensitivity of sporulation in Bacillus subtilis: a new tool for the analysis of the sporulation process [PDF]
, 1976 Jean‐Pierre Bohin +2 more
openalex +1 more source
The case for aerodynamic sensitivity analysis [PDF]
No specific solutions are offered, nor verified by applications, for its subject problem which is sensitivity analysis in Computational Fluid Dynamics (CFD).
Sobieszczanski-Sobieski, Jaroslaw
core +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Central Bank independence: A sensitivity analysis [PDF]
central banks;independence;sensitivity ...
Eijffinger, S.C.W. +2 more
core +1 more source