Results 41 to 50 of about 2,651,129 (312)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Specifying exposure classification parameters for sensitivity analysis: family breast cancer history

Clinical Epidemiology, 2009
Anne M Jurek,1,2 Timothy L Lash,3 George Maldonado41Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; 2University of Minnesota Masonic Cancer Center, Minneapolis, MN, USA; 3Department of Epidemiology, Boston University School of ...
Anne M Jurek, Timothy L Lash, George Maldonado   +2 more
doaj  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Sensitivity analysis in linear models

Special Matrices, 2016
In this work, we consider the general linear model or its variants with the ordinary least squares, generalised least squares or restricted least squares estimators of the regression coefficients and variance.
Liu Shuangzhe, Ma Tiefeng, Liu Yonghui
doaj   +1 more source

A method for uncertainty and sensitivity analysis in fuel performance codes

Brazilian Journal of Radiation Sciences, 2021
The present study proposes a method for the execution of uncertainty and sensitivity analysis on TRANSURANUS code, adapted for the use of stainless steel AISI-348 as the cladding material for a PWR reactor fuel rod, thus allowing to determine which input
Ana Carolina Bortoletto Dantas, Antonio Teixeira e Silva   +1 more
doaj   +1 more source

The determinants of democracy: a sensitivity analysis [PDF]

Public Choice, 2019
AbstractNumerous studies—operating with diverse model specifications, samples and empirical measures—suggest different economic, social, cultural, demographic, institutional and international determinants of democracy. We distinguish between democratization and democratic survival and test the sensitivities of 67 proposed determinants by varying the ...
Håvard Hegre, Håvard Hegre, Espen Geelmuyden Rød, Carl Henrik Knutsen, Carl Henrik Knutsen   +4 more
openaire   +5 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Method of hierarchical global sensitivity analysis and its application in groundwater models

地质科技通报
Objective Sensitivity analysis is an crucial tool in groundwater modelling for measuring the importance of various model inputs, enabling better allocation of limited funds and resources to reduce predictive uncertainty. Methods In this paper, we propose
Yujiao LIU, Heng DAI, Yuedong LI, Jiebo CUI, Zhang WEN   +4 more
doaj   +1 more source

Sensitivity Analysis

, 2018
Cross-cultural analysis is all about comparing groups. Whether the groups being compared are countries, ethnicities, religions, or scientific fields, the goal is always to assess whether these groups differ in some respect and to interpret those differences in substantive terms.
openaire   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source