Results 141 to 150 of about 1,462,497 (283)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Sensitivity and specificity.

, 2014
Individual sensitivities and specificities for the detection of IPA in chest radiographs without and with BSI, based on marking with a suspiciousness score above 50. * Δ = difference.Sensitivity and specificity.
Winnifred van Lankeren (639253), Nico Karssemeijer (511568), Cornelia M. Schaefer-Prokop (639256), Arlette E. Odink (639252), Sjoert A. H. Pegge (639254), Ieneke J. C. Hartmann (639250), Steven Schalekamp (639248), Bram van Ginneken (403147), Miranda M. Snoeren (639251), Inge A. H. van den Berk (639249), Laura J. Schijf (639255)   +10 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Concordance between cytopathology and incisional biopsy in the diagnosis of oral squamous cell carcinoma

Brazilian Oral Research, 2013
Oral cytopathology is a simple, non-invasive technique that could be used for early detection of oral premalignant and malignant lesions, but the effectiveness of this diagnostic approach remains controversial.
Karla Bianca Fernandes da Costa Fontes, Karin Soares Gonçalves Cunha, Fabiana Resende Rodrigues, Licínio Esmeraldo da Silva, Eliane Pedra Dias   +4 more
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Sensitivitas dan Spesifisitas Nested Polymerase Chain Reaction untuk Mendeteksi DNA Coxiella burnetii (SENSITIVITY AND SPECIFICITY OF NESTED POLYMERASE CHAIN REACTION FOR DETECTION OF COXIELLA BURNETII DNA)

Jurnal Veteriner, 2014
Sensitivity and specificity of nested polymerase chain reaction (nested PCR) to detect Coxiella burnetii(C. burnetii) DNA were studied. The primer system which consists of external primers (OMP1 and OMP2)and internal primers (OMP3 and OMP4), was designed
Trioso Purnawarman, I Wayan Teguh Wibawan, Fachriyan Hasmi Pasaribu, Agus Setiyono, Muharam Saepulloh   +4 more
doaj  

The influence of anatomical location on the accuracy of tonsillolith diagnosis on panoramic radiographs

Acta Scientiarum. Health Sciences
This study aimed to analyze the influence of anatomical location regarding the accuracy of the diagnosis of tonsilloliths on panoramic radiographs.Of 2022 digital panoramic radiographs analyzed, 181 presented tonsilloliths.
Matheus Herreira-Ferreira, Gustavo Nascimento de Souza-Pinto, Fernanda Chiguti Yamashita, Fernanda Silvestre, Breno Gabriel da Silva, Elen de Souza Tolentino, Mariliani Chicarelli, Lilian Cristina Vessoni Iwaki   +7 more
doaj   +1 more source

Sensitivity and specificity of the trichoscopy

Indian Journal of Dermatology, Venereology, and Leprology, 2012
Elzbieta, Kowalska-Oledzka, Monika, Slowinska, Adriana, Rakowska   +2 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source