Results 121 to 130 of about 1,462,497 (283)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Sensitivity, specificity, and diagnostic accuracy.

, 2019
Sensitivity, specificity, and diagnostic accuracy.
Ahmed Abdelrehem (6172181), Chi Yang (130445), Pei Shen (309502), Minjie Chen (561735), Shanyong Zhang (3853486), Manoj Kumar Sah (6172178), Yating Qiu (406707), Xiaohan Liu (477169), Shaonan Wan (6172175)   +8 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

To determine the diagnostic accuracy of visual inspection of cervix with acetic acid as a screening tool to detect preinvasive cervical cancer – A meta-analysis

Journal of Family Medicine and Primary Care
This meta-analysis was done to estimate the efficacy of visual inspection of the cervix with acetic acid (VIA) to screen for the preinvasive stage of carcinoma cervix.
Atima Bharti, Rani Hansda, Ritika Bala, Amit Kumar   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Sensitivity, specificity and clinical cut-off point of the Persian short form version of the Female Sexual Function Index (FSFI-6) [PDF]

Payesh
Objective(s): Although the psychometric properties of the Persian version of the short form of the Female Sexual Function Scale (FSFI-6) was studied, the sensitivity and specificity of the Persian version of this instrument have not been investigated ...
Raziyeh Maasoumi, Shadi Sabetghadam, Parisa Samadi, Malihe Nasiri   +3 more
doaj  

Comparison for sensitivity and specificity

, 2015
Comparison for sensitivity and ...
Kamran Shah (799893), Shaukat Ali Shah (799895), Izhar Haq (799891), Shahzad Anwar (799892), Muhammad Tahir Khan (799894)   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

CONCORDANCIA EN EL DIAGNÓSTICO CLÍNICO Y PATOLÓGICO DEL INFARTO AGUDO DE MIOCARDIO / Consistency in clinical and pathological diagnosis of acute myocardial infarction [PDF]

CorSalud, 2012
ResumenIntroducción y objetivos: El infarto agudo de miocardio continúa siendo un grave problema de salud. Su diagnóstico certero puede mejorar el pronóstico.
Omaida J. López Bernal, Ricardo Rodríguez Acosta, Ricardo Amurrio Flores, Tessa Negrín Valdés, Apolonio Palacio Cantero, Nelson F. Ocampo Ancheta   +5 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source