Results 111 to 120 of about 1,462,497 (283)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Sensitivity, specificity, positive and negative predictive values of identifying atrial fibrillation using administrative data: a systematic review and meta-analysis

Clinical Epidemiology, 2019
Ren Jie Robert Yao,1 Jason G Andrade,1 Marc W Deyell,1 Heather Jackson,2 Finlay A McAlister,3 Nathaniel M Hawkins11Division of Cardiology, University of British Columbia, Vancouver, Canada; 2Cardiac Services British Columbia, Vancouver, Canada; 3Division
Yao RJR, Andrade JG, Deyell MW, Jackson H, McAlister FA, Hawkins NM   +5 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The sensitivity, specificity, predictive values, and likelihood ratios of fecal occult blood test for the detection of colorectal cancer in hospital settings

Clinical and Experimental Gastroenterology, 2015
Salah H Elsafi,1 Norah I Alqahtani,1 Nawaf Y Zakary,2 Eidan M Al Zahrani,3 1Clinical Laboratory Science Department, Prince Sultan Military College of Health Sciences, Dhahran, 2Gastroenterology and Endoscopy Unit, Internal Medicine Department, King Fahd ...
Elsafi SH, Alqahtani NI, Zakary NY, Al Zahrani EM   +3 more
doaj  

Mechanisms of Sensitivity and Specificity in Olfaction

Cold Spring Harbor Symposia on Quantitative Biology, 1992
The sensitivity and specificity of the mammalian olfactory system is the result of the contributions at the anatomical, cellular, and biochemical levels. The recent identification of a large gene family encoding putative olfactory receptors suggests that genetic diversity may play an important role in this system. Future challenges lie in understanding
openaire   +2 more sources

Abdominal trauma--sensitivity and specificity of postmortem noncontrast imaging findings compared with autopsy findings

, 2009
The aim of the study was to determine the sensitivity and specificity for typical abdominal injuries after major blunt trauma in postmortem multislice computed tomography (MSCT) and magnetic resonance imaging (MRI)
Spendlove, Danny, Christe, Andreas, Vock, Peter, Thali, Michael J, Oesterhelweg, Lars, Ross, Steffen, Bolliger, Stephan   +6 more
core   +1 more source

Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray [PDF]

, 2010
BACKGROUND: Production of native antigens for serodiagnosis of helminthic infections is laborious and hampered by batch-to-batch variation. For serodiagnosis of echinococcosis, especially cystic disease, most screening tests rely on crude or purified ...
Maag, Eva, List, C, List, C., Gottstein, Bruno, Gottstein Bruno, Felger Ingrid, Felger, Ingrid, Qi, W, Gottstein, B., Ingrid Felger, Maag Eva, Qi Weihong, Müller, N., Felger, I, Müller, Norbert, Norbert Müller, List, Claudia, Gottstein, B, Müller Norbert, Felger, I., Maag, E., Müller, N, Qi, W., Eva Maag, Bruno Gottstein, List Claudia, Claudia List, Maag, E, Qi, Weihong, Weihong Qi   +29 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Flowchart sensitivity and specificity analysis.

, 2019
Flowchart sensitivity and specificity analysis.
Walter Devillé (56425), Hugo Tempelman (6505805)   +1 more
core   +1 more source