Results 91 to 100 of about 8,187,354 (351)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Sensitivity to runtime estimation accuracy.
, 2016 Sensitivity to runtime estimation accuracy.
Choonhwa Lee (2921532) +4 more
core +1 more source
Quantile sensitivity estimation for dependent sequences
Journal of Applied Probability, 2016 AbstractIn this paper we estimate quantile sensitivities for dependent sequences via infinitesimal perturbation analysis, and prove asymptotic unbiasedness, weak consistency, and a central limit theorem for the estimators under some mild conditions.
Jiang, Guangxin, Fu, Michael C.
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Specific formulae are derived for quadrature-based estimators of global sensitivity indices when the unknown function can be modeled by a regression plus stationary Gaussian process using the Gaussian, Bohman, or cubic correlation functions.
Svenson, Joshua +3 more
core +1 more source
Estimation results for sensitivity analyses on alternative estimation samples.
, 2019 Estimation results for sensitivity analyses on alternative estimation samples.
Peter Sivey (6786335) +3 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Efficient Estimation of Sensitivity Indices [PDF]
, 2012 41 pagesIn this paper we address the problem of efficient estimation of Sobol sensitivy indices. First, we focus on general functional integrals of conditional moments of the form $\E(\psi(\E(\varphi(Y)|X)))$ where $(X,Y)$ is a random vector with joint ...
Gamboa, Fabrice, da Veiga, Sébastien
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Carnarvon Gorge: a comment on the sensitivity of consumer surplus estimation [PDF]
Beal’s (1995) method of estimating the value of Carnarvon Gorge for recreational use is re‐examined. When an inconsistency in her estimation procedure is corrected, the estimated value of Carnarvon Gorge for camping is found to be six times higher.
Chotikapanich, Duangkamon +1 more
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