Results 21 to 30 of about 777,778 (215)
Pediatric Blood &Cancer, EarlyView.ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling +2 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
Eos, Transactions American Geophysical Union, 1992 The sensitivity of the global climate system to the initial conditions via a statistical approach was studied by Tsonis [1991]. The philosophy behind this approach was to model a global temperature record with an optimum autoregressive model ]see Katz, 1982[ and then to use this model to infer the average time that it takes for two records initially ...
openaire +1 more source
Comparison of initial and lateral boundary condition sensitivity for a limited-area model
Tellus A: Dynamic Meteorology and Oceanography, 1993 The sensitivities of two forecast aspects with respect to perturbations of initial and lateral boundary conditions are determined using an adjoint of a limited-area model. Sensitivities are presented as gradient fields. Some characteristics of the sensitivity fields have simple dynamical explanations, such as their strong dependence on winds, and do ...
Ronald M. Errico +2 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola +4 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sensitivity of Single-Column Model Solutions to Convective Parameterizations and Initial Conditions
Journal of Climate, 2001 Abstract Two sets of single-column model (SCM) simulations are performed to determine whether the SCM solutions are more sensitive to model parameterization schemes than to initial perturbations in temperature and moisture profiles. The first set of simulations (S3) used the Zhang and McFarlane scheme for the deep convection and the Hack scheme for the
Xiaoqing Wu, Mitchell W. Moncrieff
openaire +1 more source