Results 201 to 210 of about 702,487 (357)

The Relationship Between Physical Activity and Pain, Pain-Related Cognitions, and Central Sensitization in Patients With Midportion Achilles Tendinopathy. [PDF]

Orthop J Sports Med
Van Bogaert W, Potter MN, Smith AK, Smitheman HP, Matusinec ZJ, Grävare Silbernagel K.   +5 more
europepmc   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Central Sensitization as a Marker of Cognitive and Emotional Vulnerability in Chronic Low Back Pain. [PDF]

Brain Sci
Anselmo A, Cappadona I, Pagano M, Laudisio A, De Luca R, Russo F, Martello G, Cardile D, Quartarone A, Calabrò RS, Corallo F.   +10 more
europepmc   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Aeroallergen Sensitization and Its Changes in Adult Asthmatics Managed by Primary Care in the Western Yokohama, Japan. [PDF]

J Asthma Allergy
Ueno J, Tsuburai T, Komase Y, Matsushima A, Tanaka S, Muraoka H, Kaneko S, Mineshita M, Inoue T, Nishine H.   +9 more
europepmc   +1 more source

Commensal bacteria protect against food allergen sensitization

Proceedings of the National Academy of Sciences of the United States of America, 2014
A. Stefka, Taylor J. Feehley, P. Tripathi, J. Qiu, K. McCoy, S. Mazmanian, M. Tjota, Goo-Young Seo, Severine Cao, B. Theriault, D. Antonopoulos, Liang Zhou, E. Chang, Yangbo Fu, C. Nagler   +14 more
semanticscholar   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [PDF]

Eur J Immunol
Ntita M, Kong CSL, Hassan D, Nayak R, García JP, Wang Y, Chen J, Evans SE.   +7 more
europepmc   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Dual dimensions of sensitization: age-stratified and disease-associated sIgE profiles in pediatric eczema and urticaria. [PDF]

Front Nutr
Yang L, Ni J, Zhu Z, Li C, Feng X, Chen N, Fang P, Yang J, Gao K.   +8 more
europepmc   +1 more source