Results 141 to 150 of about 3,457,736 (354)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Sensor Fault Classification Based on Support Vector Machine and Statistical Time-Domain Features
, 2017 Sana Ullah Jan +3 more
openalex +1 more source
DOIDS: An Intrusion Detection Scheme Based on DBSCAN for Opportunistic Routing in Underwater Wireless Sensor Networks [PDF]
, 2023 Rui Zhang +3 more
openalex +1 more source
, 2012 Yirmi yıldan uzun süredir, pek çok yeni iletişim teknolojisinin ortaya çıkışına şahit olunmaktadır. Bunlar arasında, ağ ,optik, kızılötesi ve bluetooth örnek gösterilebilir. Pekçok araştırmacı bu konuya , bu teknolojilerin acil durumlarda kullanılması ile alanlara, özellikle de ev, ofis, klinik, fabrika, ulaşım araçları, küresel çevre ve yangın ...
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Construction of an Ultrasensitive and Highly Selective Nitrite Sensor Using Piroxicam-Derived Copper Oxide Nanostructures [PDF]
, 2018 Ali Alsalme +3 more
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source