Results 81 to 90 of about 128,877 (262)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Acknowledgement to Reviewers of Journal of Sensor and Actuator Networks in 2019

Journal of Sensor and Actuator Networks, 2020
Journal of Sensor and Actuator Networks Editorial Office
doaj   +1 more source

Improved Virtual Potential Field Algorithm Based on Probability Model in Three-Dimensional Directional Sensor Networks

International Journal of Distributed Sensor Networks, 2012
In conventional directional sensor networks, coverage control for each sensor is based on a 2D directional sensing model. However, 2D directional sensing model failed to accurately characterize the actual application scene of image/video sensor networks.
Junjie Huang, Lijuan Sun, Ruchuan Wang, Haiping Huang   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Non-contact assessment of cardiac physiology using FO-MVSS-based ballistocardiography: a promising approach for heart failure evaluation

Scientific Reports
Continuous monitoring of cardiac motions has been expected to provide essential cardiac physiology information on cardiovascular functioning. A fiber-optic micro-vibration sensing system (FO-MVSS) makes it promising.
Jing Zhan, Xiaoyan Wu, Xuelei Fu, Chenze Li, Ke-Qiong Deng, Qin Wei, Chao Zhang, Tao Zhao, Congcong Li, Longting Huang, Kewei Chen, Qiongxin Wang, Zhengying Li, Zhibing Lu   +13 more
doaj   +1 more source

A data forwarding algorithm based on Markov thought in underwater wireless sensor networks

International Journal of Distributed Sensor Networks, 2017
The underwater wireless sensor networks composed of sensor nodes are deployed underwater for monitoring and gathering submarine data. Since the underwater environment is usually unpredictable, making the nodes move or be damaged easily, such that there ...
Dongwei Li, Jingli Du, Linfeng Liu
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Energy consumption modeling of industrial robot based on simulated power data and parameter identification

Advances in Mechanical Engineering, 2018
Industrial robots consume a considerable amount of energy in the manufacturing industry. As sustainable manufacturing is one of the directions of manufacturing, the energy efficiency of the industrial robots should be considered.
Aiming Liu, Huan Liu, Bitao Yao, Wenjun Xu, Ming Yang   +4 more
doaj   +1 more source