Results 61 to 70 of about 1,443,266 (304)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
IET Wireless Sensor Systems, 2021 One of the ways in which localization algorithms in wireless sensor networks (WSNs) have been categorized is whether they are range‐based or range‐free. Range‐based algorithms use expensive hardware to measure one or more physical quantities and, in turn,
Farhan Khan, Sing Kiong Nguang
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Atmosphere, 2020 The accuracy and precision of iMET-XQ (InterMET Inc., Grand Rapids, MI, USA) temperature measurements in ten different locations on an off-the shelf rotary-wing unmanned aerial vehicle (rw-UAV) were assessed, as a function of atmospheric conditions.
Sytske K. Kimball +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2021 In a lot of countries, concrete bridges are reaching the end of their design service life. Some are suffering fromdegradation, inducing a reduced structural resistance and an increased probability of failure.
Lombaert, Geert +5 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
BioMedical Engineering OnLineBackground Human activity Recognition (HAR) using smartphone sensors suffers from two major problems: sensor orientation and placement. Sensor orientation and sensor placement problems refer to the variation in sensor signal for a particular activity due
Arnab Barua, Xianta Jiang, Daniel Fuller
doaj +1 more source