Results 81 to 90 of about 1,443,266 (304)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Effective Area Coverage of 2D and 3D Environments With Directional and Isotropic Sensors

open access: yesIEEE Access, 2020
The problem of finding the optimal deployment of sensors is becoming increasingly important with the growing expansion of the Internet of Things paradigm and increased usage of sensor networks in different applications.
Diego Susanj   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Optimal placement of a multi-sensor system

open access: yes, 2018
We consider the mathematical models for underwater acoustic sensors, the algorithm for threat detection by a multisensory system, optimization problems for placement of such systems.
Pashko, S.V.
core  

An Improved Parallel Genetic Algorithm for Optimal Sensor Placement of Wireless Sensor Networks

open access: yesInternational Journal of Information and Communication Technology Research, 2014
The wireless sensor network has recently become an intensive research focus due to its potential applications many years. Sensor placement is one of the most important issues in wireless sensor networks.
Sara Kolangari, Mohammad Teshnehlab
doaj  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A Multi-Objective Sensor Placement Method Considering Modal Identification Uncertainty and Damage Detection Sensitivity

open access: yesBuildings
Structural Health Monitoring relies on accurate modal identification and effective damage detection to assess structural performance and safety. However, traditional sensor placement methods struggle to balance modal identification uncertainty, which ...
Xue-Yang Pei   +3 more
doaj   +1 more source

In vitro protocol for validating interface pressure sensors for therapeutic compression garments: Importance of sphygmomanometer placement and initial cuff diameter

open access: yesVeins and Lymphatics, 2018
An optimal protocol is needed to validate the performance of future interface pressure sensors for compression garments when using a sphygmomanometer. PicoPress® was used on a rigid plastic cylinder (r=4 cm).
Inhwa Jung   +6 more
doaj   +1 more source

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