Results 161 to 170 of about 47,680 (217)

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

The Potential Impact of Serum Sodium and Potassium Levels on Sensorineural Hearing Loss and Tinnitus. [PDF]

J Clin Med
Maihoub S, Mavrogeni P, Mavrogenis A, Molnár A.   +3 more
europepmc   +1 more source

Magnitude, Patterns and Factors Associated With Sensorineural Hearing Loss Among Hypertensive Adults at a Tertiary Hospital in Northern Tanzania

Eye &ENT Research, Volume 3, Issue 2, Page 101-106, June 2026.
ABSTRACT Background Hearing loss affects 1.5 billion people globally, with sensorineural hearing loss (SNHL) linked to hypertension. Hypertension affects 1.39 billion people worldwide and its prevalence is rising sharply in Sub‐Saharan Africa. While 12% of Tanzanian population has cardiovascular diseases, including hypertension and recent studies ...
Johnson Shayo, Denis Katundu, Abdallah Jonas, Peter Shija   +3 more
wiley   +1 more source

Impact of contralateral sensorineural hearing loss on prognosis in idiopathic sudden sensorineural hearing loss. [PDF]

PLoS One
Xie S, Chen Z, Huang L, Hong Y, Lin C.
europepmc   +1 more source

Heimler Syndrome Caused by Novel <i>PEX6</i> Variants: Clinical and Genetic Characterization in a Saudi Cohort. [PDF]

Genes (Basel)
AlMoallem B.
europepmc   +1 more source

A case of cryopyrin-associated periodic syndrome presenting with abdominal symptoms due to a novel mutation NLRP3 p.Ile257Met. [PDF]

Clin J Gastroenterol
Komatsu Y, Oizumi T, Yanai SI, Kobayashi Y, Nishio SY, Usami SI, Matsumoto T.   +6 more
europepmc   +1 more source

Adjunctive Hyperbaric Oxygen Therapy or Intratympanic Steroids in Sudden Sensorineural Hearing Loss?

The Laryngoscope, Volume 136, Issue 6, Page 2708-2718, June 2026.
Sudden sensorineural hearing loss is traditionally treated with steroids, either orally and/or via intratympanic injections, and hyperbaric oxygen treatment (HBOT) has resurged in popularity as an adjunctive therapy. The study has not found any additional treatment benefit with adjunctive concurrent HBOT; however, HBOT might be of value to patients ...
Jennifer L. Spiegel, Michael J. De Biasio, Gianluca Sampieri, Omer J. Ungar, Munir D. Bajin, Vincent Y. W. Lin, Joseph M. Chen, Chris Idestrup, Jordan Tarshis, Trung N. Le   +9 more
wiley   +1 more source

Increased incidence of sudden sensorineural hearing loss in patients with rheumatoid arthritis: a nationwide propensity-matched cohort study. [PDF]

Clinics (Sao Paulo)
Chen MJ, Lee YC, Chen MY, Chung CH, Chien WC, Lin DY, Wu YF, Lee KH.   +7 more
europepmc   +1 more source

Screaming‐Induced Acute Noise Exposure During Pediatric Ear Procedures

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
Pediatric ENT procedures can generate rapid spikes in noise exposure due to patient screaming. Real‐time LAeq and cumulative dose measurements showed that recommended limits may be exceeded within minutes. These findings highlight acute acoustic risks for healthcare providers and the need for sensory‐adapted care environments.
Jun‐Ya Kita, Hiroshi Nakanishi, Asuno Tamakoshi, Masataka Sone, Sosuke Sahara, Kiyoshi Misawa   +5 more
wiley   +1 more source