Results 201 to 210 of about 93,748 (336)

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

open access: yesAdvanced Science, Volume 12, Issue 46, December 11, 2025.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen   +9 more
wiley   +1 more source

Longitudinal Insights into Sensorineural and Noise-Induced Hearing Loss in Adolescents Aged 13-18 Years. [PDF]

open access: yesOtolaryngol Head Neck Surg
Abstract Objective To describe the prevalence of sensorineural hearing loss (SNHL) and probable noise‐induced hearing loss (NIHL) among 18‐year‐olds, and to examine changes in prevalence and severity between ages 13 and 18. Study Design Data were obtained from the Generation R Study, a prospective birth cohort in Rotterdam, the Netherlands.
Reijers SNH   +6 more
europepmc   +2 more sources

LHFPL5 splice site variant in a cat with deafness and vestibular dysfunction

open access: yesAnimal Genetics, Volume 56, Issue 6, December 2025.
Abstract Vestibular disorders associated with hearing loss are indicative of inner ear dysfunction. We investigated a young cat presenting with deafness and vestibular signs. Magnetic resonance imaging of the brain revealed no abnormalities. No obvious visual impairment was reported on ophthalmological examination.
Assami‐Carina Perret   +3 more
wiley   +1 more source

Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.
ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone   +13 more
wiley   +1 more source

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