Results 221 to 230 of about 93,748 (336)

M/G‐Ratio‐Tuned Calcium Alginate Hydrogel Microcarrier for Controlled Delivery of Adeno‐Associated Virus for Gene Therapy

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 12, Page 3433-3445, December 2025.
ABSTRACT This paper proposes the controlled release of adeno‐associated virus (AAV) by polymer mesh structures of alginate hydrogel microbeads (gel‐beads). The polymer mesh structure of alginate hydrogel can be controlled by adjusting the number of cross‐linking points depending on the molecular structure (M/G ratio) of the alginate hydrogel.
Aiki Hioki   +3 more
wiley   +1 more source

Hearing Loss and Chiari Malformation Type I: A Scoping Review. [PDF]

open access: yesDiseases
Migliorelli A   +6 more
europepmc   +1 more source

Delivery strategies of messenger RNA therapeutics for brain disorders

open access: yesBulletin of the Korean Chemical Society, Volume 46, Issue 12, Page 1186-1204, December 2025.
Thus, mRNA therapeutics offer a powerful new avenue for the treatment of brain diseases. This review examines strategies to bypass biological barriers, particularly the blood–brain barrier, and explores emerging delivery systems, such as direct intracerebral injection, intracerebroventricular injection, systemic delivery (including intravenous ...
Kounghwa Youn   +5 more
wiley   +1 more source

Mitochondrial Disease Diagnosed Following Preterm Birth at 29 Weeks of Gestation and Postpartum Heart Failure: A Case Report and Literature Review

open access: yesClinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT In some cases, mitochondrial disease can remain undiagnosed until pregnancy reveals systemic symptoms. Clinicians should therefore consider this diagnosis in young patients presenting with diabetes, kidney disease, and hearing loss. Early diagnosis can improve maternal and fetal outcomes, particularly in high‐risk pregnancies complicated by ...
Tomoyuki Watanabe   +2 more
wiley   +1 more source

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