Results 81 to 90 of about 139,963 (293)

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

Advanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen, Hui Zhang, Jiayi Li, Xianmei Wei, Chenjie Yu, Yuanjin Zhao, Maoli Duan, Xiaoyun Qian, Xia Gao   +8 more
wiley   +1 more source

Prevalence of congenital hereditary sensorineural deafness in Australian Cattle Dogs and associations with coat characteristics and sex

BMC Veterinary Research, 2012
BackgroundCongenital hereditary sensorineural deafness (CHSD) occurs in many dog breeds, including Australian Cattle Dogs. In some breeds, CHSD is associated with a lack of cochlear melanocytes in the stria vascularis, certain coat characteristics, and ...
S. Sommerlad, J. Morton, M. Haile-Mariam, I. Johnstone, J. Seddon, C. O'Leary   +5 more
semanticscholar   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Sensorineural Deafness Among Patients with Chronic Renal Failure in Al-kindi Teaching Hospital

مجله كليه طب الكندي, 2011
Background: Patients with chronic kidney disease have different grades of sensorineural deafness . Objective: To study the incidence of sensorineural hearing loss and possible contributing factors in patients with chronic kidney disease.
Raad Aboud Aloubaide, Ali Jassim Alsaedi, Raed Saker, Nawar Satta Jamil, Faris Abbass Mohammed   +4 more
doaj  

Mitochondrial dysfunction in hearing loss: Oxidative stress, autophagy and NLRP3 inflammasome

Frontiers in Cell and Developmental Biology, 2023
Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction plays a vital role of in the pathogenesis of deafness.
Peipei Li, Peipei Li, Shen Li, Le Wang, Hongmin Li, Yang Wang, Hongbing Liu, Xin Wang, Xiaodan Zhu, Zhangsuo Liu, Zhangsuo Liu, Fanglei Ye, Yuan Zhang   +12 more
doaj   +1 more source

Indian Sign Language Recognition Using Mediapipe Holistic [PDF]

arXiv, 2023
Deaf individuals confront significant communication obstacles on a daily basis. Their inability to hear makes it difficult for them to communicate with those who do not understand sign language. Moreover, it presents difficulties in educational, occupational, and social contexts.
arxiv  

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.

Journal of Clinical Investigation, 2011
Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification of single-gene causes of SRNS has generated some insights into its pathogenesis; however, additional genes and disease mechanisms remain obscure ...
S. Heeringa, G. Chernin, M. Chaki, Weibin Zhou, A. Sloan, Ziming Ji, Letian X. Xie, L. Salviati, T. Hurd, V. Vega-Warner, P. Killen, Y. Raphael, S. Ashraf, Bugsu Ovunc, D. Schoeb, H. Mclaughlin, R. Airik, C. Vlangos, R. Gbadegesin, Bernward Hinkes, P. Saisawat, E. Trevisson, Mara Doimo, A. Casarín, V. Pertegato, Gianpietro Giorgi, H. Prokisch, A. Rötig, G. Nürnberg, C. Becker, Su-qing Wang, F. Ozaltın, R. Topaloğlu, A. Bakkaloğlu, S. Bakkaloğlu, D. Müller, Antje Beissert, S. Mir, A. Berdeli, Seza Varpizen, M. Zenker, Verena Matejas, C. Santos-Ocaña, P. Navas, T. Kusakabe, A. Kispert, S. Akman, Neveen A. Soliman, S. Krick, P. Mundel, J. Reiser, P. Nürnberg, C. Clarke, R. Wiggins, C. Faul, F. Hildebrandt   +55 more
semanticscholar   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea

Advanced Science, EarlyView.
This study indicates that Serpine2 plays a pivotal role in hair cell (HC) regeneration from Lgr5+ progenitors in the neonatal mouse cochlea. Conditional overexpression of Serpine2 in cochlear Lgr5+ progenitors results in a significantly increased number of ectopic HCs, particularly ectopic inner HCs, and these HCs are likely derived from Lgr5 ...
Hairong Xiao, Jiheng Wu, Lixuan Huang, Ying Ma, Leilei Wu, Yanqin Lin, Zixuan Ye, Xin Tan, Xujun Tang, Wei Tong, Mingchen Dai, Yintao Wang, Xia Sheng, Renjie Chai, Shasha Zhang   +14 more
wiley   +1 more source