Results 71 to 80 of about 39,003 (229)

Sound Descriptions of Haptic Experiences of Art Work by Deafblind Cochlear Implant Users

Multimodal Technologies and Interaction, 2018
Deafblind persons’ perception and experiences are based on their residual auditive and visual senses, and touch. Their haptic exploration, through movements and orientation towards objects give blind persons direct, independent experience.
Riitta Lahtinen, Camilla Groth, Russ Palmer   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Visuospatial working memory as a predictor of gait performance in adults with normal hearing and hearing aid users

Discover Psychology
Background Age-related hearing loss affects a significant portion of older adults and is associated not only with communication difficulties but also with mobility impairments, including reduced walking ability. Prior research suggests that auditory cues
Francesca Molinari Luccini, Henrik Danielsson, Victoria Stenbäck, Elaine Hoi Ning Ng, Emil Holmer   +4 more
doaj   +1 more source

Children’s Glasgow Sensory Questionnaire (C-GSQ): Validation of a Simplified and Visually Aided Questionnaire Research Assistant Lecturer

This study aimed to validate an adaptation of the Glasgow Sensory Questionnaire (GSQ) – an adult self-report measure of sensory reactivity – intended for use with children aged between 8 and 11. Initially, 234 children filled out this adapted questionnaire with visual comprehension aids, while their caregivers completed the Autism Spectrum Quotient ...
Elliot Millington, Lauren Brown, Holly McMahon, Ashley E. Robertson, David Simmons   +4 more
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Muddy, muddled, or muffled? Understanding the perception of audio quality in music by hearing aid users

Frontiers in Psychology
IntroductionPrevious work on audio quality evaluation has demonstrated a developing convergence of the key perceptual attributes underlying judgments of quality, such as timbral, spatial and technical attributes.
Scott Bannister, Alinka E. Greasley, Trevor J. Cox, Michael A. Akeroyd, Jon Barker, Bruno Fazenda, Jennifer Firth, Simone N. Graetzer, Gerardo Roa Dabike, Rebecca R. Vos, William M. Whitmer   +10 more
doaj   +1 more source