Results 51 to 60 of about 59,777 (278)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Les contes, un laboratoire des sens : augmentation sensorielle, polysensorialité et synesthésies

open access: yesFééries, 2019
In tales, sense augmentation first appeared through the folk-literature motif of “the gifted”, or “persons with extraordinary powers”. In the 18th century, however, the exploration of the possibilities opened by the senses, echoing with sensualist ...
Aurélia Gaillard
doaj   +1 more source

Visual Error Augmentation for Enhancing Motor Learning and Rehabilitative Relearning [PDF]

open access: yes, 2005
We developed a real-time controller for a 2 degree-of-freedom robotic system using xPC Target. This system was used to investigate how different methods of performance error feedback can lead to faster and more complete motor learning in individuals ...
Bajaj, Preeti   +3 more
core   +1 more source

Adding generic contextual capabilities to wearable computers [PDF]

open access: yes, 1998
Context-awareness has an increasingly important role to play in the development of wearable computing systems. In order to better define this role we have identified four generic contextual capabilities: sensing, adaptation, resource discovery, and ...
Pascoe, Jason
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Backward spatial perception can be augmented through a novel visual-to-auditory sensory substitution algorithm

open access: yesScientific Reports, 2021
Can humans extend and augment their natural perceptions during adulthood? Here, we address this fascinating question by investigating the extent to which it is possible to successfully augment visual spatial perception to include the backward spatial ...
Ophir Netzer   +4 more
doaj   +1 more source

Manifesto for Digital Social Touch in Crisis

open access: yesFrontiers in Computer Science, 2021
This qualitative exploratory research paper presents a Manifesto for Digital Social Touch in Crisis - a provocative call to action to designers, developers and researchers to rethink and reimagine social touch through a deeper engagement with the social ...
Carey Jewitt   +11 more
doaj   +1 more source

TESSA - Toolkit for experimentation with multimodal sensory substitution and augmentation [PDF]

open access: yes, 2015
TESSA is a toolkit for experimenting with sensory augmentation. It includes hardware and software to facilitate rapid prototyping of interfaces that can enhance one sense using information gathered from another sense.
Hwang, Faustina, Sainz Martinez, Carlos
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Sensory supplementation system based on electrotactile tongue biofeedback of head position for balance control [PDF]

open access: yes, 2008
The present study aimed at investigating the effects of an artificial head position-based tongue-placed electrotactile biofeedback on postural control during quiet standing under different somatosensory conditions from the support surface.
Asai   +43 more
core   +3 more sources

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