Results 41 to 50 of about 698,517 (173)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Sensory Augmentation for Public Space

, 2018
Sensory augmentation for public space explores the innovation potential of sensory augmentation interfaces to improve public space. Technological innovations for public spaces are typically developed for the mobile phone.
de Rooij, Alwin, de Rooij, Alwin; id_orcid, van Dartel, Michel   +2 more
core   +1 more source

Improving Tracking through Human-Robot Sensory Augmentation

, 2021
This letter introduces a sensory augmentation technique enabling a contact robot to understand its human user's control in real-time and integrate their reference trajectory information into its own sensory feedback to improve the tracking performance ...
Etienne Burdet (37376)
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Using a Vibrotactile Biofeedback Device to Augment Foot Pressure During Walking in Healthy Older Adults: A Brief Report

Frontiers in Psychology, 2019
Human movement based on sensory control is significant to motor task performance. Thus, impairments to sensory input significantly limit feedback-type motor control.
Kazuhiro Yasuda, Yuki Hayashi, Anna Tawara, Hiroyasu Iwata   +3 more
doaj   +1 more source

Backward spatial perception can be augmented through a novel visual-to-auditory sensory substitution algorithm

Scientific Reports, 2021
Can humans extend and augment their natural perceptions during adulthood? Here, we address this fascinating question by investigating the extent to which it is possible to successfully augment visual spatial perception to include the backward spatial ...
Ophir Netzer, Benedetta Heimler, Amir Shur, Tomer Behor, Amir Amedi   +4 more
doaj   +1 more source

Manifesto for Digital Social Touch in Crisis

Frontiers in Computer Science, 2021
This qualitative exploratory research paper presents a Manifesto for Digital Social Touch in Crisis - a provocative call to action to designers, developers and researchers to rethink and reimagine social touch through a deeper engagement with the social ...
Carey Jewitt, Sara Price, Jürgen Steimle, Gijs Huisman, Lili Golmohammadi, Narges Pourjafarian, William Frier, Thomas Howard, Sima Ipakchian Askari, Michela Ornati, Sabrina Panëels, Judith Weda   +11 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source