Results 71 to 80 of about 117,891 (311)

Revealing the neural fingerprints of a missing hand

open access: yeseLife, 2016
The hand area of the primary somatosensory cortex contains detailed finger topography, thought to be shaped and maintained by daily life experience. Here we utilise phantom sensations and ultra high-field neuroimaging to uncover preserved, though latent,
Sanne Kikkert   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

CARE TEAM EDUCATION ON THE USE OF SENSORY RESOURCES IN INPATIENT PSYCHIATRY [PDF]

open access: yes, 2016
Sensory processing is the way the nervous system receives, organizes, and understands sensory information gained through our body’s senses and physical environment.
Hoque, Salsabil
core   +1 more source

The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]

open access: yes, 2017
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A.   +32 more
core   +2 more sources

Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity. [PDF]

open access: yesPLoS ONE, 2011
Sensory experience, and the lack thereof, can alter the function of excitatory synapses in the primary sensory cortices. Recent evidence suggests that changes in sensory experience can regulate the synaptic level of Ca(2+)-permeable AMPA receptors (CP ...
Anubhuti Goel   +8 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Food after deprivation rewards the earlier eating [PDF]

open access: yes, 2005
Food intake can be increased by learning to anticipate the omission of subsequent meals. We present here a new theory that such anticipatory eating depends on an associative process of instrumental reinforcement by the nutritional repletion that occurs ...
David A. Booth   +76 more
core   +3 more sources

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

A study of flotation-REST (restricted environmental stimulation therapy) as an insomnia treatment [PDF]

open access: yesSleep Science
Objectives: Flotation-REST is a treatment for deep relaxation, where a person is contained in a stimuli-restricted environment and floats in water with high salt content.
Annika Norell-Clarke   +4 more
doaj   +1 more source

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