Results 51 to 60 of about 117,570 (284)

Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences

Neural Plasticity, 2012
The central nervous system architecture is highly dynamic and continuously modified by sensory experience through processes of neuronal plasticity. Plasticity is achieved by a complex interplay of environmental influences and physiological mechanisms ...
José Fernando Maya-Vetencourt, Nicola Origlia   +1 more
doaj   +1 more source

Lamina-specific AMPA receptor dynamics following visual deprivation in vivo. [PDF]

, 2020
Regulation of AMPA receptor (AMPAR) expression is central to synaptic plasticity and brain function, but how these changes occur in vivo remains elusive.
Cudmore, Robert H, Graves, Austin R, Huganir, Richard L, Roth, Richard H, Tan, Han L   +4 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

BALANCING SENSORY STIMULATION/DEPRIVATION FROM THE ENVIRONMENT IN HEALTH-FORMING TECHNOLOGIES

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale
The Medicine of the near future will develop not only along the path of improving diagnostics, treatment, rehabilitation, but also through the development of technologies for the formation (promotion) of health, human enhancement, and work productivity ...
Anatolie BACIU
doaj   +1 more source

Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function

Cell Reports, 2019
Summary: This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input.
Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie   +2 more
doaj   +1 more source

THE USE OF SENSORY DEPRIVATION IN PATIENTS WITH LONG-TERM CONSEQUENCES OF MILD COMBAT TRAUMATIC BRAIN INJURY

Медична наука України, 2020
Relevance. Traumatic brain injury (TBI) and its consequences often lead to disability, the progression of both the syndromes that arise after trauma and comorbid pathology.
V.O. Korshnyak, A.N. Stoyanov, I.O. Ostapenko, O.A. Hruzevskyi   +3 more
doaj   +1 more source

Molecular implications of prolonged aggression experience: Th, Dat1, Snca and Bdnf gene expression in the ventral tegmental area of the victorious male mice [PDF]

, 2008
Th, Dat1, Snca and Bdnf were the genes whose mRNA levels in the ventral tegmental area of the midbrain were measured in male mice that were victorious in 20 daily agonistic interactions and in a group of such victorious mice that had later not been ...
Irina L. Kovalenko, Maxim L. Filipenko, Natalia N. Kudryavtseva, Natalia P. Bondar, Ul'   +4 more
core   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Recovery of node of ranvier structure in optic nerve under visual deprivation

Neuroscience Research
Neural activity can increase the length of nodes of Ranvier (NOR) and slow impulse transmission; however, little is known about the biologically and clinically important recovery process.
Erin Santos, William C. Huffman, R. Douglas Fields   +2 more
doaj   +1 more source

Anhedonia in the shadow of chronic social defeat stress, or When the experimental context matters [PDF]

, 2008
One of the core symptoms of major depression in human is anhedonia. For that reason, one of the main requirements towards experimental depression models is that they be able to demonstrate anhedonia in animals, that have been exposed to stressful events,
Damira F. Avgustinovich, Dmitry A. Smagin, Irina L. Kovalenko, Natalia N. Kudryavtseva, Natalia P. Bondar   +4 more
core   +1 more source