Results 51 to 60 of about 41,852 (284)

BALANCING SENSORY STIMULATION/DEPRIVATION FROM THE ENVIRONMENT IN HEALTH-FORMING TECHNOLOGIES

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale
The Medicine of the near future will develop not only along the path of improving diagnostics, treatment, rehabilitation, but also through the development of technologies for the formation (promotion) of health, human enhancement, and work productivity ...
Anatolie BACIU
doaj   +1 more source

Visual Experience Regulates the Intrinsic Excitability of Visual Cortical Neurons to Maintain Sensory Function

Cell Reports, 2019
Summary: This in vivo study shows that both intrinsic and sensory-evoked synaptic properties of layer 2/3 neurons in mouse visual cortex are modified by ongoing visual input.
Alexander P.Y. Brown, Lee Cossell, Troy W. Margrie   +2 more
doaj   +1 more source

THE USE OF SENSORY DEPRIVATION IN PATIENTS WITH LONG-TERM CONSEQUENCES OF MILD COMBAT TRAUMATIC BRAIN INJURY

Медична наука України, 2020
Relevance. Traumatic brain injury (TBI) and its consequences often lead to disability, the progression of both the syndromes that arise after trauma and comorbid pathology.
V.O. Korshnyak, A.N. Stoyanov, I.O. Ostapenko, O.A. Hruzevskyi   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Recovery of node of ranvier structure in optic nerve under visual deprivation

Neuroscience Research
Neural activity can increase the length of nodes of Ranvier (NOR) and slow impulse transmission; however, little is known about the biologically and clinically important recovery process.
Erin Santos, William C. Huffman, R. Douglas Fields   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

The Impact of Ecological Niche on Adaptive Flexibility of Sensory Circuitry

Frontiers in Neuroscience, 2017
Evolution and development are interdependent, particularly with regard to the construction of the nervous system and its position as the machine that produces behavior.
Sarah L. Pallas
doaj   +1 more source

Sensory Deprivation and Sensory Reinforcement with Shock

, 1966
Groups of rats were raised from weaning under normal animal colony conditions and conditions of reduced sensory stimulation. In a shuttle box groups of 5, 2, and 2 showed acquisition for mild shock proportional to degree of deprivation ( P < .02). In
Gordon M. Harrington, Glenn R. Kohler
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source