Results 41 to 50 of about 117,570 (284)

Cross-Modal Plasticity Results in Increased Inhibition in Primary Auditory Cortical Areas

Neural Plasticity, 2013
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex.
Yu-Ting Mao, Sarah L. Pallas
doaj   +1 more source

Considerations about rodent models of binge eating episodes [PDF]

, 2014
A binge eating episode is defined as an uncontrolled event of hyperphagia, in which people quickly eat a large amount of food while feeling a sense of loss of control over eating (Wolfe et al., 2009).
Garcia Romero, Guadalupe, Perello, Mario, Raingo, Jesica, Valdivia Torres, Lesly Spring   +3 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Sleep deprivation disrupts postural balance and sensorimotor integration: A combined psychophysiological–behavioral analysis

NeuroImage
Background: Sleep is crucial for optimal sensorimotor integration, a fundamental process enabling coordinated motor responses to sensory inputs. However, the neurophysiological mechanisms through which acute sleep deprivation impairs this integration ...
Lin Xu, Lei Peng, Xin An, Xiao Zhong, Yongcong Shao, Yuefang Dong, Weiwei Fu   +6 more
doaj   +1 more source

Effects of hunger state on flavour pleasantness conditioning at home: flavour-nutrient learning vs. flavour-flavour learning [PDF]

, 2007
This study examined acquired liking of flavour preferences through flavour-flavour and flavour-nutrient learning under hungry or sated conditions in a naturalistic setting.
Ackroff, Ackroff, Ackroff, Alexy, Appleton, Baeyens, Berkey, Birch, Booth, Booth, Booth, Booth, Booth, Booth, Brunstrom, Capaldi, Capaldi, De Houwer, Elizalde, Fedorchak, Gibson, Gibson, Johnson, Kern, Looy, Looy, Lucas, Lucy C. Chambers, Martin R. Yeomans, Meiselman, Mobini, Myers, Myers, Myers, Myers, Richardson, Rogers, Sclafani, Sclafani, Sclafani, Sclafani, Sirous Mobini, Steiner, Stevenson, Stevenson, Stevenson, Tinley, Warwick, Yeomans, Yeomans, Yeomans, Yeomans, Yiin, Zellner, Zellner   +54 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sensory Deprivation and Patient

Eurasian Journal of Medicine, 2019
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Türkan Pasinlioğlu
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Sensory Deprivation or Postictal Vulnerability? Psychosis Following Phenytoin-Induced Toxic Epidermal Necrolysis – A Case Report

Kerala Journal of Psychiatry
Background: Acute cutaneous and mucosal manifestations of drug-induced toxic epidermal necrolysis are well recognized. Ocular complications lead to visual impairment and sensory deprivation and may predispose to psychosis.
Sthuthi Shireen, Aiswarya R Kamath, Bindu Menon   +2 more
doaj   +1 more source