Results 31 to 40 of about 41,852 (284)

Brain Activation for Audiovisual Information in People With One Eye Compared to Binocular and Eye-Patched Viewing Controls

Frontiers in Neuroscience, 2020
Blindness caused by early vision loss results in complete visual deprivation and subsequent changes in the use of the remaining intact senses. We have also observed adaptive plasticity in the case of partial visual deprivation.
Stefania S. Moro, Stefania S. Moro, Stefania S. Moro, Diana J. Gorbet, Diana J. Gorbet, Jennifer K. E. Steeves, Jennifer K. E. Steeves, Jennifer K. E. Steeves   +7 more
doaj   +1 more source

The Impact of Sensory; Linguistic and Social Deprivation on Cognition

, 2017
Early experience plays a crucial role in determining the trajectory of cognitive development. For example, early sensory deprivation is known to induce neural reorganization by way of adaptation to the altered sensory experience.
Matthew Dye, Olivier Pascalis
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Response to short-term deprivation of the human adult visual cortex measured with 7T BOLD

eLife, 2018
Sensory deprivation during the post-natal ‘critical period’ leads to structural reorganization of the developing visual cortex. In adulthood, the visual cortex retains some flexibility and adapts to sensory deprivation. Here we show that short-term (2 hr)
Paola Binda, Jan W Kurzawski, Claudia Lunghi, Laura Biagi, Michela Tosetti, Maria Concetta Morrone   +5 more
doaj   +1 more source

Mature and precursor brain-derived neurotrophic factor have individual roles in the mouse olfactory bulb. [PDF]

PLoS ONE, 2012
Sensory deprivation induces dramatic morphological and neurochemical changes in the olfactory bulb (OB) that are largely restricted to glomerular and granule layer interneurons.
Thomas Gerald Mast, Debra Ann Fadool
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sleep deprivation disrupts postural balance and sensorimotor integration: A combined psychophysiological–behavioral analysis

NeuroImage
Background: Sleep is crucial for optimal sensorimotor integration, a fundamental process enabling coordinated motor responses to sensory inputs. However, the neurophysiological mechanisms through which acute sleep deprivation impairs this integration ...
Lin Xu, Lei Peng, Xin An, Xiao Zhong, Yongcong Shao, Yuefang Dong, Weiwei Fu   +6 more
doaj   +1 more source

Sensory Deprivation during Early Postnatal Period Alters the Density of Interneurons in the Mouse Prefrontal Cortex

Neural Plasticity, 2015
Early loss of one sensory system can cause improved function of other sensory systems. However, both the time course and neuronal mechanism of cross-modal plasticity remain elusive.
Hiroshi Ueno, Shunsuke Suemitsu, Yosuke Matsumoto, Motoi Okamoto   +3 more
doaj   +1 more source

Evanescence of Sensory Deprivation Effects: A Comment on Oleson and Zubek's “Effect of One Day of Sensory Deprivation …”

, 1971
Oleson and Zubek (1970) found that sensory deprivation for 24 hr. did not produce significant deterioration in creative thinking and offered several possible explanations for this datum.
Peter Suedfeld
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source