Results 141 to 150 of about 5,916,094 (333)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Faktor Risiko Kejadian Kurang Pendengaran Tipe Sensorik pada Bayi Baru Lahir [PDF]

, 2011
The risk factors of sensory type of hearing loss in newborn babyBackground: The influence of risk factors (RF) of hearing loss (HL) varies from birth until many years of live.
Kosim, M. S. (M), Muyassaroh, M. (Muyassaroh), Suprihati, S. (Suprihati)   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of dual sensory impairment on dementia: A systematic review and meta‐analysis

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Hearing and vision loss are considered independent modifiable risk factors for dementia; however, the impact of their dual impairment is not clear and is crucial for preventive strategies. We performed a systematic review and meta‐analysis until July 23,
Daniele Urso, Stefano Giannoni‐Luza, Ahmed Amine Alaoui, Jeremy Ting, Samir Jabbour, Adrian Fuente, Giancarlo Logroscino   +6 more
doaj   +1 more source

Sensory changes related to breeding for plant architecture and resistance to viruses and anthracnose in bean market class Fabada (Phaseolus vulgaris L.) [PDF]

, 2014
Consumers hold landraces in high esteem and often consider that breeding programs lead to a loss of sensory quality, although consumers’ opinions have not been scientifically confirmed.
Casañas, F., Castillo, R.R. (Romero), Ferreira, J.J. (J.), Plans, M., Pérez-Vega, E., Simó, J.   +5 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss

Neuroscience, 2019
Prior work has provided extensive documentation of threshold sensitivity and sensory hair cell losses after noise exposure. It is now clear, however, that cochlear synaptic loss precedes such losses, at least at low-moderate noise doses, silencing ...
K. Fernandez, Dan Guo, Steven B Micucci, V. Gruttola, M. Liberman, Sharon G. Kujawa, Sharon G. Kujawa   +6 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Uma comparação das interações sensoriais entre Espanha e Portugal. Os resultados de um workshop de design sinestésico [PDF]

, 2019
: Synaesthesia is the result of automatic processes of human perception that combine sensations of different sensory modalities. Throughout this paper, we are going to present the results of a Synaesthetic Design Workshop, made with design students of
Duarte, Emilia Capucho, Gambera, David Antonio, Riccó, Dina   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source