Results 121 to 130 of about 303,068 (314)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The effect of processing on sensory properties of mayonnaise [Elektronisk resurs]

, 2017
Introduction Mayonnaise is an oil in water emulsion, generally produced in high intensity rotor-stator mixers. The taste, flavour and texture is appreciated by consumers but local markets value different sensory properties.
Forsberg, Sarah,, Kristianstad University., Olsson, Viktoria,, Svensson, Therése,, Purhagen, Jeanette,, Wendin, Karin,, Håkansson, Andreas,   +6 more
core  

Chemical, Physical, and Sensory Properties of Bread with Popped Amaranth Flour

This study investigated the effect of substitution of wheat flour with popped amaranth flour in bread formulation on the chemical, physical, and sensory characteristics of breads. The raw and popped amaranth grain flours of four Peruvian varieties: Oscar
Guadalupe Chaquilla-Quilca, Alma Rosa Islas-Rubio, Chaquilla-Quilca, Guadalupe, Francisco Vásquez-Lara, Lourdes Salcedo-Sucasaca, Jesús Guadalupe Luna-Valdez, Silva-Paz, Reynaldo Justino, Reynaldo Justino Silva-Paz, Luna-Valdez, Jesús Guadalupe, Islas-Rubio, Alma Rosa, Vásquez-Lara, Francisco, Salcedo-Sucasaca, Lourdes   +11 more
core   +1 more source

Instrumental and sensory textural properties of Fura

, 2002
A uniaxial compression test and sensory textural analysis was conducted of fura samples made from millet flour. Significant differences (p < 0.05) existed among the samples for hardness (the force to compress the sample between molar teeth ...
Jideani, Victoria A
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons

, 2002
Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons.
Schimmang, Thomas, Lewin, G. R., Lewin, Gary R, Klein, R.*, Klein, R., Lewin, G.R., Fritzsch, B., Minichiello, L.*, Calella, A. M., Minichiello, Liliana, Klein, Rüdiger, Katz, David, Eilers, A., Schimmang, T., Minichiello, L., Lewin, G., Katz, D., Postigo, A., Calella, A.M., *Corresponding authors, Calella, A., Fritzsch, Bernd, Knipper, M., Postigo, Antonio, Eilers, Andreas, Calella, Anna Maria, Knipper, Marlies   +26 more
core   +1 more source

Determining Which Cooking Method Provides the Best Sensory Differentiation of Potatoes

, 2020
There are many ways to prepare potatoes that each provide a unique set of sensory properties. However, when conducting a descriptive sensory study, it is important to utilize a cooking method that will highlight, and not distract from, the sensory ...
Delores Chambers, Martin Talavera, Edgar Chambers IV, Melissa Ciccone   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source