Results 61 to 70 of about 235,651 (257)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Effect of Multi Sensory Stimulation (MSS) on Cognitive Disturbances and Quality of Life of Male Patients with Alzheimer’s Disease

Iranian Rehabilitation Journal, 2012
Objectives: Alzheimer’s disease causes many negative effects on the individual's physical, psychological and cognitive conditions. The multi sensory stimulation helps the patients to improve their physical, psychological and cognitive conditions ...
Mahdi Mahboubinia, Asghar Dalvandi, Kian Nourozi, Nasrin Mahmoudi, Shadi Sadat Safavi, Samaneh Hosseinzadeh   +5 more
doaj  

Repetitive tactile stimulation changes resting-state functional connectivity – implications for treatment of sensorimotor decline

Frontiers in Human Neuroscience, 2012
Neurological disorders and physiological aging can lead to a decline of perceptual abilities. In contrast to the conventional therapeutic approach that comprises intensive training and practicing, passive repetitive sensory stimulation (RSS) has recently
Frank eFreyer, Frank eFreyer, Frank eFreyer, Matthias eReinacher, Matthias eReinacher, Guido eNolte, Hubert R Dinse, Petra eRitter, Petra eRitter, Petra eRitter, Petra eRitter   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sensory Memory Workshop: An account of experience

Cadernos Brasileiros de Terapia Ocupacional, 2019
Introduction: Across the world, population aging can lead to the emergence of chronic degenerative diseases, among them, the major neurocognitive disorder (TNM) known as dementia. It’s a syndrome characterized by cognitive, perceptual and sensory losses
Marinara de Alcantara, Emanuela Bezerra Torres Mattos, Marcia Maria Pires Camargo Novelli   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sensory stimulation—A way of creating mutual relations in dementia care

International Journal of Qualitative Studies on Health & Well-Being, 2014
The overall aim of this 2-year Norwegian action research study was to improve the interaction between care workers and patients with dementia in a nursing home by means of sensory stimulation.
Else Lykkeslet, Eva Gjengedal, Torill Skrondal, May-Britt Storjord   +3 more
doaj   +1 more source

Acupuncture-Stimulated Activation of Sensory Neurons

Journal of Acupuncture and Meridian Studies, 2012
Acupuncture is one of the key therapeutics in clinical oriental medicine, and recent studies using experimental animals have begun to provide the pathophysiological basis for the efficacy of acupuncture. Here, we investigated neuronal responses in rodent models given acupuncture stimulation.
Kim, Min-Hee, Park, Yang-Chun, Namgung, Uk   +2 more
openaire   +2 more sources