Results 71 to 80 of about 235,651 (257)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Sensory and memory stimulation as a means to care for individuals with dementia in long-term care facilities

Clinical Interventions in Aging, 2018
Michael Mileski, Joseph Baar Topinka, Matthew Brooks, Corie Lonidier, Kelly Linker, Kelsey Vander Veen School of Health Administration, Texas State University, San Marcos, TX, USA Objective: The primary objective of this study was to identify and ...
Mileski M, Baar Topinka J, Brooks M, Lonidier C, Linker K, Vander Veen K   +5 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Decreasing the incidence of delirium via multi-sensory stimulation in patients receiving mechanical ventilation in the intensive care unit: A protocol for a randomized feasibility study

Contemporary Clinical Trials Communications
Introduction: Delirium is a common acute brain dysfunction syndrome in patients admitted to intensive care units (ICUs). Family engagement strategies, based on the theory of multi-sensory stimulation to ameliorate sensory deprivation in patients, may be ...
Bin He, Bei-rong Mo, Si-ya Meng, Zheng Yang, Wen-ting Liu, Yu-ying Wang, Xiao-Ling Mou, Yu-Qi Chen, Yu Chen   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

EEG oscillatory changes following rehabilitative tactile and thermal stimulation in disorders of consciousness: a longitudinal and pilot study

Frontiers in Neuroscience
IntroductionRecent advances in the understanding of sensory processing in disorders of consciousness (DoC) have highlighted the potential of exteroceptive stimuli, particularly tactile stimulation. Unlike auditory or visual inputs, tactile stimuli engage
Caterina Formica, Simona De Salvo, Elvira Gjonaj, Serena Dattola, Angelo Quartarone, Antonella Alagna, Jolanda De Caro, Anna Lisa Logiudice, Carmela Rifici, Silvia Marino   +9 more
doaj   +1 more source

Effect of Multimodal Sensory Stimulation on Consciousness and Cognitive Function for Patients with Acute Stroke. [PDF]

Egyptian Journal of Health Care
Background: Consciousness disorders are very serious consequences of acute stroke; therefore, patients need enough safe sensory stimuli to enhance cognitive and consciousness performance.
Sheren Mohammed Diab, Zeinab Faried Bahgat, Asmaa Ibrahem Abo Seada, Rokia Ibrahim EL Nagar   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex.

Frontiers in Neural Circuits, 2015
Invariant sensory coding is the robust coding of some sensory information (e.g. stimulus type) despite major changes in other sensory parameters (e.g. stimulus strength).
Nathan S Jacobs, Nathan S Jacobs, Cynthia H Chen-Bee, Cynthia H Chen-Bee, Ron D Frostig, Ron D Frostig, Ron D Frostig   +6 more
doaj   +1 more source