Results 31 to 40 of about 26,200,033 (292)

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Arthritis Research & Therapy, 2019
Background Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial zone (SFZ) of articular cartilage.
Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito   +14 more
doaj   +1 more source

Sensitive and selective phenol sensing in denitrifying Aromatoleum aromaticum EbN1T

Microbiology Spectrum, 2023
Aromatoleum aromaticum EbN1T anaerobically degrades phenol, p-cresol, and p-ethylphenol, each via a distinct peripheral pathway. The compound-specific regulation of each pathway is proposed to occur on the transcriptional level in the case of phenol ...
Ramona Buschen, Pia Lambertus, Sabine Scheve, Simon Horst, Fei Song, Lars Wöhlbrand, John Neidhardt, Michael Winklhofer, Tristan Wagner, Ralf Rabus   +9 more
doaj   +1 more source

Midterm results of revision total hip arthroplasty for migrated bipolar hemiarthroplasty in patients with hip osteoarthritis using cementless cup with the rim-fit technique

Journal of Orthopaedic Surgery, 2020
Purpose: The results of reamed bipolar hemiarthroplasty (BHA) in patients with hip osteoarthritis (OA) are reported to be unfavorable. Acetabular reaming for sufficient bony coverage caused bipolar head migration into the superomedial direction, and most
Takeyuki Tanaka, Taizo Kaneko, Ryo Hidaka, Kazuaki Hashikura, Hisatoshi Ishikura, Toru Moro, Sakae Tanaka   +6 more
doaj   +1 more source

Transplanting Neural Progenitor Cells into a Chronic Dorsal Column Lesion Model

Biomedicines, 2022
Cell transplantation therapy is a promising strategy for spinal cord injury (SCI) repair. Despite advancements in the development of therapeutic strategies in acute and subacute SCI, much less is known about effective strategies for chronic SCI.
Kazuo Hayakawa, Ying Jin, Julien Bouyer, Theresa M. Connors, Takanobu Otsuka, Itzhak Fischer   +5 more
doaj   +1 more source

Receptors, channels, and signalling in the urothelial sensory system in the bladder. [PDF]

Nat Rev Urol, 2016
The storage and periodic elimination of urine, termed micturition, requires a complex neural control system to coordinate the activities of the urinary bladder, urethra, and urethral sphincters.
Merrill L, Gonzalez EJ, Girard BM, Vizzard MA.   +3 more
europepmc   +2 more sources

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Nature Communications, 2019
Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathway.
Song Ho Chang, Daisuke Mori, Hiroshi Kobayashi, Yoshifumi Mori, Hideki Nakamoto, Keita Okada, Yuki Taniguchi, Shurei Sugita, Fumiko Yano, Ung-il Chung, Joo-ri Kim-Kaneyama, Motoko Yanagita, Aris Economides, Ernesto Canalis, Di Chen, Sakae Tanaka, Taku Saito   +16 more
doaj   +1 more source

Walking-Related Dual-Task Interference in Early-to-Middle-Stage Huntington's Disease: An Auditory Event Related Potential Study

Frontiers in Psychology, 2017
Objective: To compare interference between walking and a simple P3 auditory odd-ball paradigm in patients with Huntington's disease (HD) and age- and sex-matched controls.Methods: Twenty-four early-to-middle-stage HD patients and 14 age- and sex-matched ...
Marina de Tommaso, Katia Ricci, Anna Montemurno, Eleonora Vecchio, Sara Invitto   +4 more
doaj   +1 more source

A calibratable sensory neuron based on epitaxial VO2 for spike-based neuromorphic multisensory system

Nature Communications, 2022
Neuromorphic perception systems inspired by biology have tremendous potential in efficiently processing multi-sensory signals from the physical world, but a highly efficient hardware element capable of sensing and encoding multiple physical signals is ...
Rui Yuan, Qingxi Duan, Pek Jun Tiw, Ge Li, Zhuojian Xiao, Zhaokun Jing, Ke Yang, Chang Liu, Chen Ge, Ru Huang, Yuchao Yang   +10 more
semanticscholar   +1 more source

Capsaicin-Induced Skin Desensitization Differentially Affects A-Delta and C-Fiber-Mediated Heat Sensitivity

Frontiers in Pharmacology, 2020
Localized neuropathic pain can be relieved following the topical application of high-concentration capsaicin. This clinical effect is thought to be related to the temporary desensitization of capsaicin- and heat-sensitive epidermal nociceptors.
Sabien G. A. van Neerven, André Mouraux
doaj   +1 more source

Epilepsy and the Sensory Systems [PDF]

Epilepsy Currents, 2016
The relations of epilepsy and the sensory systems are bidirectional. Epilepsy may act on sensory systems by producing sensory seizure symptoms, by altering sensory performance, and by epilepsy treatment causing sensory side effects. Sensory system activity may have an important role in both generation and inhibition of seizures.
openaire   +2 more sources