Results 41 to 50 of about 84,211 (253)

Comparison of Thresholds between Bipolar and Monopolar Electrical Cortical Stimulation

Neurologia Medico-Chirurgica, 2022
Electrical cortical stimulation is widely performed and is the gold standard for functional mapping in intractable epilepsy patients; however, a standard protocol has not yet been established.
Yasuhiro TAKAHASHI, Rei ENATSU, Aya KANNO, Seiichiro IMATAKA, Shoichi KOMURA, Tomoaki TAMADA, Kyoya SAKASHITA, Ryohei CHIBA, Takuro SAITO, Nobuhiro MIKUNI   +9 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Validation of a Brazilian quantitative sensory testing (QST) device for the diagnosis of small fiber neuropathies

Arquivos de Neuro-Psiquiatria, 2011
Quantitative sensory testing (QST) is defined as the determination of thresholds for sensory perception under controlled stimulus. Our aim was to validate a new QST device for Brazilian sample. In 20 healthy adults, thermoalgesic thresholds were assessed
Pedro Schestatsky, Luciana Cadore Stefani, Paulo Roberto Sanches, Danton Pereira da Silva Júnior, Iraci Lucena Silva Torres, Letizzia Dall-Agnol, Luciane Fachin Balbinot, Wolnei Caumo   +7 more
doaj   +1 more source

Sensory Percepts Elicited by Chronic Macro-Sieve Electrode Stimulation of the Rat Sciatic Nerve

Frontiers in Neuroscience, 2021
Objective: Intuitive control of conventional prostheses is hampered by their inability to provide the real-time tactile and proprioceptive feedback of natural sensory pathways.
Nikhil S. Chandra, Weston M. McCarron, Ying Yan, Luis C. Ruiz, Eric G. Sallinger, Nathan K. Birenbaum, Harold Burton, Leonard Green, Daniel W. Moran, Wilson Z. Ray, Matthew R. MacEwan   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Sensory Modulation Dysfunction in Child Victims of Trauma from four residential care sites in Southern Gauteng, South Africa.

South African Journal of Occupational Therapy, 2022
Introduction The ability to modulate sensory input or the way an individual responds to sensory information, to create an appropriate adaptive response may be influenced by exposure to trauma.
Rowena Yasmin Joseph, Janine van der Linde, Denise Franzsen   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mechanical and Thermal Sensory Testing in Normal Chondrodystrophoid Dogs and Dogs with Spinal Cord Injury caused by Thoracolumbar Intervertebral Disc Herniations

Journal of Veterinary Internal Medicine, 2016
Background Intervertebral disc herniation is a common cause of spinal cord injury (SCI) causing paralysis and sensory loss. Little quantitative information is available on the loss and recovery of sensation in dogs with SCI.
A.M. Gorney, S.R. Blau, C.S. Dohse, E.H. Griffith, K.D. Williams, J.‐H. Lim, D. Knazovicky, B.D.X. Lascelles, N.J. Olby   +8 more
doaj   +1 more source

Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss. [PDF]

PLoS ONE, 2012
The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills.
Merri J Rosen, Emma C Sarro, Jack B Kelly, Dan H Sanes   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source