Results 61 to 70 of about 88,053 (254)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Preliminary Analysis of the Relationship Between Acupoint Sensitivity and Inter-acupoint Distance Along the 12 Meridians

Journal of Acupuncture Research
Although the spatial organization of the acupoints is a fundamental element in acupuncture practice, its physiological relevance has not been fully established.
You-Jeong Han, Gyoungeun Park , Ga-young Kim, Jung-Eun Jang, Won-Suk Sung, Kyung-Ho Kim, Seung-Deok Lee   +6 more
doaj   +1 more source

Linking sensory processing patterns and somatosensory thresholds to behavioural and emotional symptoms in adolescents with ADHD

Scientific Reports
Sensory difficulties in attention deficit hyperactivity disorder (ADHD) exacerbate behavioural and emotional challenges. Despite their clinical prevalence, objective psychophysical assessments of sensory performance in ADHD patients remain scarce ...
Dicle Buyuktaskin, İrem Aktar-Songür, Ahmet Özaslan, Zeynep Kübra Kurt, Esra Guney, Elvan Iseri, Zafer Gunendi, Bulent Cengiz   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Dissociation Between Subjective Sensory Reactivity and Visual Perceptual Sensitivity in Autistic and Non‐Autistic Adults: A Brief Report

Brain and Behavior
Background Autistic individuals frequently report atypical sensory experiences, typically assessed using self‐ or proxy‐report questionnaires such as the Sensory Profile. However, it remains unclear whether these subjective reports reflect differences in
Caroline Candy, Declan Ryan, Elizabeth Milne, Abigail Dickinson   +3 more
doaj   +1 more source

Visual nudging of navigation strategies improves frequency discrimination during auditory-guided locomotion

Frontiers in Neuroscience
Perception in natural environments requires integrating multisensory inputs while navigating our surroundings. During locomotion, sensory cues such as vision and audition change coherently, providing crucial environmental information.
Annalenia Malzacher, Annalenia Malzacher, Tobias Hilbig, Tobias Hilbig, Michael Pecka, Dardo N. Ferreiro, Dardo N. Ferreiro   +6 more
doaj   +1 more source

The Effect of Granisetron on Sensory Detection and Pain Thresholds in Facial Skin of Healthy Young Males

Frontiers in Neurology, 2020
Background: The specific serotonin type 3 (5-HT3)-receptor antagonist granisetron effectively reduces clinical as well as experimental muscle pain and hyperalgesia and with a duration that exceeds that of lidocaine.
Malin Ernberg, Anna Wieslander Fältmars, Milad Hajizadeh Kopayeh, Sofia Arzt Wallén, Therese Cankalp, Nikolaos Christidis   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effects of acupuncture on sensory perception: a systematic review and meta-analysis.

PLoS ONE, 2014
BackgroundThe effect of acupuncture on sensory perception has never been systematically reviewed; although, studies on acupuncture mechanisms are frequently based on the idea that changes in sensory thresholds reflect its effect on the nervous system ...
Petra I Baeumler, Johannes Fleckenstein, Shin Takayama, Michael Simang, Takashi Seki, Dominik Irnich   +5 more
doaj   +1 more source