Results 81 to 90 of about 92,239 (294)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Dissociation Between Subjective Sensory Reactivity and Visual Perceptual Sensitivity in Autistic and Non‐Autistic Adults: A Brief Report

Brain and Behavior
Background Autistic individuals frequently report atypical sensory experiences, typically assessed using self‐ or proxy‐report questionnaires such as the Sensory Profile. However, it remains unclear whether these subjective reports reflect differences in
Caroline Candy, Declan Ryan, Elizabeth Milne, Abigail Dickinson   +3 more
doaj   +1 more source

The Effect of Granisetron on Sensory Detection and Pain Thresholds in Facial Skin of Healthy Young Males

Frontiers in Neurology, 2020
Background: The specific serotonin type 3 (5-HT3)-receptor antagonist granisetron effectively reduces clinical as well as experimental muscle pain and hyperalgesia and with a duration that exceeds that of lidocaine.
Malin Ernberg, Anna Wieslander Fältmars, Milad Hajizadeh Kopayeh, Sofia Arzt Wallén, Therese Cankalp, Nikolaos Christidis   +5 more
doaj   +1 more source

Dissociation of phantom limb phenomena from stump tactile spatial acuity and sensory thresholds

, 2005
Most amputees experience phantom limb sensations and/or phantom limb pain as well as residual limb (stump) pain that are resistant to treatment. Phantom phenomena are not homogeneous; each patient presents with a unique combination of spontaneous or ...
Katz, Joel, Hunter, Judith P., Davis, Karen   +2 more
core  

The relationship between persistent pain and tactile sensory and pain pressure thresholds in postmastectomy breast cancer patients: A preliminary report.

, 2021
Introduction:Persistent postmastectomy pain is common among breast cancer patients. The relationship of persistentpostmastectomy pain (PPP) with sensory loss and increased pain sensitization remains unclear. In this study, we investigated therelationship
Balta, Selin, Kozanhan, Betül, Eryılmaz, Mehmet Ali, Çetingök, Halil   +3 more
core   +1 more source

The sensory threshold for faradic stimulation in man. [PDF]

Psychological Review, 1913
n ...
Martin, E. G., Porter, E. L., Nice, L. B.   +2 more
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Visual nudging of navigation strategies improves frequency discrimination during auditory-guided locomotion

Frontiers in Neuroscience
Perception in natural environments requires integrating multisensory inputs while navigating our surroundings. During locomotion, sensory cues such as vision and audition change coherently, providing crucial environmental information.
Annalenia Malzacher, Annalenia Malzacher, Tobias Hilbig, Tobias Hilbig, Michael Pecka, Dardo N. Ferreiro, Dardo N. Ferreiro   +6 more
doaj   +1 more source

Effects of acupuncture on sensory perception: a systematic review and meta-analysis.

PLoS ONE, 2014
BackgroundThe effect of acupuncture on sensory perception has never been systematically reviewed; although, studies on acupuncture mechanisms are frequently based on the idea that changes in sensory thresholds reflect its effect on the nervous system ...
Petra I Baeumler, Johannes Fleckenstein, Shin Takayama, Michael Simang, Takashi Seki, Dominik Irnich   +5 more
doaj   +1 more source