Results 91 to 100 of about 88,053 (254)

Pain perception in autism. A study of sensory reactivity in children and adolescents with autism using quantitative sensory testing and psychophysiological correlates

Frontiers in Neuroscience
BackgroundHyper- or hypo-reactivity to sensory input is a diagnostic criterion for autism spectrum disorder; however, it is still not fully characterized, despite its relevance to patients' quality of life.
Valentina Nicolardi, Isabella Fanizza, Giuseppe Accogli, Sara Scoditti, Antonio Trabacca   +4 more
doaj   +1 more source

Thresholds for Fufu Sensory Properties

Fufu, a staple food in West Africa, is highly valued for its texture, flavor, and color—attributes that significantly influence consumer acceptability. This study aimed to determine the threshold levels of key fufu sensory attributes using a combination of Quantitative Descriptive Analysis (QDA), instrumental texture and color measurements, and ...
CHIJIOKE, UGO, Okonkwo, Justice, IRO, Ugochi Jane, UDOKA, Precious, Osodeke, Chinyere Sonia, Achonwa, Oluchi, Anedo, Emmanuel, Abah, Simon Peter, UMEZURUMBA, Ogechi, CHIKERE, Juliet, OBASI, Ijeoma, Madu, Tessy, Okoye, Benjamin, EJECHI, Mercy, Nwafor, Solomon, Nnaemeka C, Onyemauwa, Ofoeze, Miriam Ahunna, Ukeje, Blessing Adanma, Onwuka, Samuel, ELUAGU, Chinwe   +19 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

REPEATABILITY AND RELIABILITY OF A NEW THERMOTACTILE QUANTITATIVE SENSORY TESTING ALGORITHM

Zdravniški Vestnik, 2009
Background Thermotactile quantitative sensory testing (TQST), as a part of quantitative sensory testing (QST), has been used for quantifying perceived thermal sensory thresholds.
Maruša Klopčič, Miroljub Jakovljević
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Improved Acuity and Dexterity but Unchanged Touch and Pain Thresholds following Repetitive Sensory Stimulation of the Fingers

Neural Plasticity, 2012
Neuroplasticity underlies the brain’s ability to alter perception and behavior through training, practice, or simply exposure to sensory stimulation.
Rebecca Kowalewski, Jan-Christoph Kattenstroth, Tobias Kalisch, Hubert R. Dinse   +3 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source