Results 111 to 120 of about 92,239 (294)

Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children

, 2012
Background: Autism spectrum conditions have a strong genetic component. Atypical sensory sensitivities are one of the core but neglected features of autism spectrum conditions. GABRB3 is a well-characterised candidate gene for autism spectrum conditions.
Simon Baron-Cohen, Tavassoli Teresa, Bonnie Auyeung, Bhismadev Chakrabarti, Baron-Cohen, Simon, Laura C Murphy, Murphy Laura C, Murphy, Laura; id_orcid, Auyeung, Bonnie, Chakrabarti Bhismadev, Auyeung Bonnie, Murphy, Laura C., Baron-Cohen Simon, Auyeung, Bonnie; id_orcid, Teresa Tavassoli, Chakrabarti, Bhismadev, Tavassoli, Teresa, Chakrabarti, Bhisma   +17 more
core   +1 more source

Quantitative sensory testing of temperature thresholds: Possible biomarkers for persistent pain? [PDF]

, 2015
To investigate the reproducibility of thermal thresholds, as measured by repeated quantitative sensory testing (QST) in healthy controls, and to asses if temperature sensitivity differs between healthy controls and a cohort of patients with persistent ...
E Malmström, Westergren, Hans, H Westergren, Högestätt, Edward, J Stjerna, E Högestätt, Malmström, Eva-Maj, Stjerna, Johanna   +7 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Development of visuo-auditory integration in space and time

Frontiers in Integrative Neuroscience, 2012
Adults integrate multisensory information optimally (e.g. Ernst & Banks, 2002) while children are not able to integrate multisensory visual haptic cues until 8-10 years of age (e.g. Gori, Del Viva, Sandini, & Burr, 2008).
Monica eGori, Giulio eSandini, David eBurr, David eBurr   +3 more
doaj   +1 more source

The measurement of vascular and neurological function in workers exposed to hand-transmitted vibration

, 1999
Four methods for measuring disorders of vascular function and neurological function associated with occupational exposure to hand-transmitted vibration have been defined by reference to the available literature.
Lindsell, Christopher John, Lindsell, C.J.   +1 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

REPEATABILITY AND RELIABILITY OF A NEW THERMOTACTILE QUANTITATIVE SENSORY TESTING ALGORITHM

Zdravniški Vestnik, 2009
Background Thermotactile quantitative sensory testing (TQST), as a part of quantitative sensory testing (QST), has been used for quantifying perceived thermal sensory thresholds.
Maruša Klopčič, Miroljub Jakovljević
doaj  

Sensory disturbances in complex regional pain syndrome: Clinical observations, autonomic interactions, and possible mechanisms

, 2010
To review mechanisms that might contribute to sensory disturbances and sympathetically-maintained pain in complex regional pain syndrome (CRPS). CRPS is associated with a range of sensory and autonomic abnormalities.
Drummond, P.D.
core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source