Results 71 to 80 of about 92,239 (294)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch

Acta Dermato-Venereologica, 2018
While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood.
Zoe Lewis, David N. George, Fiona Cowdell, Henning Holle   +3 more
doaj   +1 more source

The developmental status and prevalence of sensory integration difficulties in premature infants in a tertiary hospital in Bloemfontein, South Africa

South African Journal of Occupational Therapy, 2016
Introduction and aim: Research indicates that premature infants are at risk of neurological abnormalities and developmental and functional delays during infancy and early childhood.
Elise Lecuona, Annamarie van Jaarsveld, Rita van Heerden, Jacques Raubenheimer   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Preliminary Analysis of the Relationship Between Acupoint Sensitivity and Inter-acupoint Distance Along the 12 Meridians

Journal of Acupuncture Research
Although the spatial organization of the acupoints is a fundamental element in acupuncture practice, its physiological relevance has not been fully established.
You-Jeong Han, Gyoungeun Park , Ga-young Kim, Jung-Eun Jang, Won-Suk Sung, Kyung-Ho Kim, Seung-Deok Lee   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds

, 2008
BACKGROUND: Calcitonin was effective in a study of acute phantom limb pain, but it was not studied in the chronic phase. The overall literature on N-methyl-D-aspartate antagonists is equivocal.
Eichenberger, Urs, Arendt-Nielsen, Lars, Neff, Frank, Frank Neff, Steen Petersen-Felix, Petersen-Felix, Steen, Urs Eichenberger, Steinar Björgo, Gorazd Sveticic, Lars Arendt-Nielsen, Michele Curatolo, Curatolo, Michele, Sveticic, Gorazd, Björgo, Steinar   +13 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Tactile feedback improves auditory spatial localization

Frontiers in Psychology, 2014
Our recent studies suggest that congenitally blind adults have severely impaired thresholds in an auditory spatial-bisection task, pointing to the importance of vision in constructing complex auditory spatial maps (Gori et al., 2014).
Monica eGori, Tiziana eVercillo, Giulio eSandini, David eBurr   +3 more
doaj   +1 more source

Evaluation of threshold limit methods for sensory data

Water Science and Technology, 2007
Current approaches to sensory thresholds, such as geometric means and logistic regression, ignore any formal consideration of uncertainty and variability. Various alternative methods based on approximate confidence and prediction intervals about the logistic regression were examined.
D, Gallagher, J, Cuppett
openaire   +2 more sources