Results 51 to 60 of about 926,604 (274)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Sentiment analysis of epidemiological surveillance reports on COVID-19 in Greece using machine learning models

Frontiers in Public Health, 2023
The present research deals with sentiment analysis performed with Microsoft Azure Machine Learning Studio to classify Facebook posts on the Greek National Public Health Organization (EODY) from November 2021 to January 2022 during the pandemic. Positive,
Christos Stefanis, Elpida Giorgi, Konstantinos Kalentzis, Athanasios Tselemponis, Evangelia Nena, Christina Tsigalou, Christos Kontogiorgis, Yiannis Kourkoutas, Ekaterini Chatzak, Ioannis Dokas, Theodoros Constantinidis, Eugenia Bezirtzoglou   +11 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Royal Birth of 2013: Analysing and Visualising Public Sentiment in the UK Using Twitter [PDF]

, 2013
Analysis of information retrieved from microblogging services such as Twitter can provide valuable insight into public sentiment in a geographic region. This insight can be enriched by visualising information in its geographic context.
Barker, Adam, Nguyen, Vu Dung, Varghese, Blesson   +2 more
core   +2 more sources

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Evaluation datasets for Twitter sentiment analysis: a survey and a new dataset, the STS-Gold [PDF]

, 2013
Sentiment analysis over Twitter offers organisations and individuals a fast and effective way to monitor the publics' feelings towards them and their competitors.
Alani, Harith, Fernández, Miriam, He, Yulan, Saif, Hassan   +3 more
core   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Sentiment Analysis Using the Vader Model for Assessing Company Services Based on Posts on Social Media

SEEU Review, 2023
The provision of services by companies in specific domains requires continuous commitment and a constructive approach to meet customer requirements, however, it is often challenging to determine the level of customer satisfaction without their feedback ...
Hoti Mërgim H., Ajdari Jaumin
doaj   +1 more source

General Framework for Domain-Specialization of Stance Detection

Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2021
We present a generalized framework for domain-specialized stance detection, focusing on Covid-19 as a use case. We define a stance as a predicate-argument structure (combination of an action and its participants) in a simplified one-argument format, e.g.,
Brodie Mather, Bonnie J Dorr, Owen Rambow, Tomek Strzalkowski   +3 more
doaj   +1 more source